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Arecoline hydrobromide

Name: Arecoline hydrobromide
Brand: TargetMol
SKU: T2198
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2198Cas No. 300-08-3

Alias Arecoline HBr, Arecoline bromide

Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.

Arecoline hydrobromide

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Purity: 99.52%

Catalog No. T2198Alias Arecoline HBr, Arecoline bromideCas No. 300-08-3

Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$40	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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Product Introduction

Arecoline hydrobromide AI Summary

Arecoline hydrobromide is a versatile bioactive molecule exhibiting multiple pharmacological activities. It acts as an agonist of the endothelin A receptor, causing a significant vascular endothelium-dependent relaxation at a concentration of 10E-5 M/L with a relaxation effect of over 50.0%. Additionally, it shows agonism toward the Muscarinic acetylcholine receptor M3, enhancing the contraction rate of isolated guinea pig ileum by more than 50.0%. Although it shows inhibitory activity against HIV1 RT with an IC50 value greater than 200.0 μg/mL, its potential as an antiviral agent remains uncertain. Further, Arecoline hydrobromide inhibits the proliferation of Plasmodium falciparum and acts as a potent inhibitor of Bloom's syndrome helicase (BLM) and Histone Lysine Methyltransferase G9a. It also inhibits HP1-beta Chromodomain interactions with methylated histone tails and induces DNA re-replication in SW480 colon adenocarcinoma cells. The compound activates the transient receptor potential cation channel C4, although it does not significantly activate the transient receptor potential channel N1. It also shows inhibitory activity in the Nrf2 screen and has an agonistic effect on the transient receptor potential channel ML3. Additionally, Arecoline hydrobromide inhibits electric eel AChE by 16.92% and horse BChE by 0.29% at 2 mg/mL using Ellman's method. It demonstrates high inhibitory activity in sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM, with inhibition percentages of 103.72% and 112.58%, respectively. In antiviral assays, Arecoline hydrobromide shows promising activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 uM after 48 hours, with inhibition rates of -3.17% and 0.68%, respectively. It also inhibits the SARS-CoV-2 3CL-Pro protease by 21.03% at a concentration of 20 µM, as detected through a FRET response from a peptide substrate. Overall, Arecoline hydrobromide demonstrates a broad spectrum of bioactivity including antiviral, anticancer, and enzyme inhibitory properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.
Synonyms	Arecoline HBr, Arecoline bromide

Chemical Properties

Molecular Weight	236.11
Formula	C₈H₁₃NO₂·HBr
Cas No.	300-08-3
Smiles	Br.COC(=O)C1=CCCN(C)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (211.77 mM), Sonication is recommended.

H2O: 100 mg/mL (423.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.2353 mL	21.1766 mL	42.3531 mL	211.7657 mL
5 mM	0.8471 mL	4.2353 mL	8.4706 mL	42.3531 mL
10 mM	0.4235 mL	2.1177 mL	4.2353 mL	21.1766 mL
20 mM	0.2118 mL	1.0588 mL	2.1177 mL	10.5883 mL
50 mM	0.0847 mL	0.4235 mL	0.8471 mL	4.2353 mL
100 mM	0.0424 mL	0.2118 mL	0.4235 mL	2.1177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc