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Anti-Bim Antibody (4L851)
😃Good
Catalog No. TMAB-03148
Anti-Bim Antibody (4L851) is a Rabbit antibody targeting Bim. Anti-Bim Antibody (4L851) can be used in WB.
Anti-Bim Antibody (4L851)
Anti-Bim Antibody (4L851)
😃Good
Catalog No. TMAB-03148
Anti-Bim Antibody (4L851) is a Rabbit antibody targeting Bim. Anti-Bim Antibody (4L851) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Bim Antibody (4L851) is a Rabbit antibody targeting Bim. Anti-Bim Antibody (4L851) can be used in WB. |
| Ig Type | IgG |
| Clone | 4L851 |
| Reactivity | Human,Mouse (predicted:Rat) |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion. |
| Tissue Specificity | Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Bim, Bcl-2 interacting mediator of cell death, is a pro-apoptotic protein belonging to the Bcl2 family of proteins containing a Bcl2 homology domain 3 (BH3). It is proapoptotic and exerts its effects by interacting with prosurvival members of the Bcl2 family like Bcl2, BclxL and Bclw. Bim is sequestered in an inactive conformation through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release Bim from microtubules, allowing inhibitory binding to anti-apoptotic Bcl-2 family members and subsequent iniation of apoptosis. |
| Immunogen | KLH conjugated synthetic peptide: human Bim |
| Antigen Species | Human |
| Gene Name | BCL2L11 |
| Gene ID | |
| Protein Name | Bcl-2-like protein 11 |
| Uniprot ID | |
| Function | Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis. |
| Molecular Weight | Theoretical: 22 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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