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MLT-748

Name: MLT-748
Brand: TargetMol
SKU: T16120
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16120Cas No. 1832578-30-9

Alias MLT748, MLT 748

MLT-748 is a MALT1 allosteric inhibitor that inhibits the growth of lung cancer cells. MLT-748 acts by blocking the protein hydrolyzing activity of MALT1.

MLT-748

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Purity: 99.62%

Catalog No. T16120Alias MLT748, MLT 748Cas No. 1832578-30-9

MLT-748 is a MALT1 allosteric inhibitor that inhibits the growth of lung cancer cells. MLT-748 acts by blocking the protein hydrolyzing activity of MALT1.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$393	-	In Stock
25 mg	$588	-	In Stock
50 mg	$787	-	In Stock
100 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$268	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MLT-748 is a MALT1 allosteric inhibitor that inhibits the growth of lung cancer cells. MLT-748 acts by blocking the protein hydrolyzing activity of MALT1.
Targets&IC50	MALT1 (329-728-W580S):13 nM (Kd), MALT1 (329-728):42 nM (Kd), MALT1:5 nM
In vitro	In immortalized B cells from MALT1mut/mut patients, MLT-748 (2 µM; 24 hours) increased phosphorylation levels of NF-κB signaling pathway components p65 and IκBα as early as 5 minutes after stimulation with PMA and ionomycin.
Synonyms	MLT748, MLT 748

Chemical Properties

Molecular Weight	492.32
Formula	C₁₉H₁₉Cl₂N₉O₃
Cas No.	1832578-30-9
Smiles	CO[C@H](C)[C@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (507.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0312 mL	10.1560 mL	20.3120 mL	101.5600 mL
5 mM	0.4062 mL	2.0312 mL	4.0624 mL	20.3120 mL
10 mM	0.2031 mL	1.0156 mL	2.0312 mL	10.1560 mL
20 mM	0.1016 mL	0.5078 mL	1.0156 mL	5.0780 mL
50 mM	0.0406 mL	0.2031 mL	0.4062 mL	2.0312 mL
100 mM	0.0203 mL	0.1016 mL	0.2031 mL	1.0156 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc