JSD26

Name: JSD26
Brand: TargetMol
SKU: T213924
Rating: 4.5 (1 reviews)

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JSD26 is a selective orally active inhibitor of SCoR2 (AKR1A1) with an IC50 of 93 nM, demonstrating 10 times the selectivity for SCoR2 over AKR1B1. It is utilized in research related to acute kidney injury (AKI).

JSD26

Cas No. 2353515-08-7

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	4-6 weeks	4-6 weeks
50 mg	$1,980	4-6 weeks	4-6 weeks
100 mg	$2,500	4-6 weeks	4-6 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	JSD26 is a selective orally active inhibitor of SCoR2 (AKR1A1) with an IC50 of 93 nM, demonstrating 10 times the selectivity for SCoR2 over AKR1B1. It is utilized in research related to acute kidney injury (AKI).
Targets & IC50	SCoR2:93 nM
In vivo	JSD26 (20-120 mg/kg, intraperitoneal injection, single administration) is a selective inhibitor of SCoR2, effectively suppressing SCoR2 in mice without affecting AKR1B1. At a dosage of 120 mg/kg, JSD26 relieves symptoms of acute kidney injury (AKI) in mice by selectively inhibiting SCoR2 and increasing S-nitrosylation of PKM2.

Chemical Properties

Molecular Weight	290.32
Formula	C₁₈H₁₄N₂O₂
Cas No.	2353515-08-7
Smiles	O=C1NC(=O)C2(N1)C=3C=CC=CC3C4=CC=C(C=C42)C5CC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.