CCR4 Protein-VLP, Human, Recombinant (His)

Name: CCR4 Protein-VLP, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPH-01065
Rating: 4.5 (1 reviews)

(Synonyms: K5-5, CMKBR4, CD194, CCR-4, CCR4, CC-CKR-4, C-C CKR-4, C-C chemokine receptor type 4) Copy Product Info

Synonyms: K5-5, CMKBR4, CD194, CCR-4, CCR4, CC-CKR-4, C-C CKR-4, C-C chemokine receptor type 4

Catalog No. TMPH-01065 Copy Product Info

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.

CCR4 Protein-VLP, Human, Recombinant (His)

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Pack Size	Price	USA Stock	Global Stock
5 µg	$275	20 days	20 days
10 µg	$459	20 days	20 days
20 µg	$776	20 days	20 days
50 µg	$1,270	20 days	20 days
100 µg	$1,870	20 days	20 days
200 µg	$3,150	20 days	20 days
500 µg	$6,280	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 10 μg/mL can bind Anti-CCR4 recombinant antibody, the EC 50 is 362.3-630.8 ng/mL.
Description	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.
Species	Human
Expression System	HEK293 Cells
Tag	C-10xHis (This tag can be tested only under denaturing conditions)
Accession Number	P51679
Amino Acid	MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
Construction	1-360 aa
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	PBS, pH 7.4, 6% trehalose
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	K5-5, CMKBR4, CD194, CCR-4, CCR4, CC-CKR-4, C-C CKR-4, C-C chemokine receptor type 4
Research Background	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Chemical Properties

Molecular Weight

43.2 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.