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TC-O 9311

Name: TC-O 9311
Brand: TargetMol
SKU: T4626L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4626LCas No. 444932-31-4

Alias TCO-9311, TC-O-9311, TC-O9311, TCO9311, TC-O 9311, TCO 9311

TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).

TC-O 9311

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Purity: 99.84%

Catalog No. T4626LAlias TCO-9311, TC-O-9311, TC-O9311, TCO9311, TC-O 9311, TCO 9311Cas No. 444932-31-4

TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
25 mg	$84	In Stock	In Stock
50 mg	$127	In Stock	In Stock
100 mg	$189	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

TC-O 9311 AI Summary

TC-O 9311 exhibits agonist activity at the human GPR139 receptor, as assessed through calcium mobilization using the FLIPR assay, with an Emax value of 125.0% and an EC50 value of 43.0 nM. It also shows antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells with an inhibition rate of 11.84% at 10 µM concentration after 48 hours, and demonstrating a 0.32% inhibition rate in VERO-6 cells under similar conditions. Furthermore, it inhibits SARS-CoV-2 3CL-Pro protease by 17.36% at 20µM in a FRET-based assay. In enzymatic assays, TC-O 9311 shows a 9.39% inhibition of human HDAC6 with a commercial peptide substrate, but only -0.28% inhibition with a custom peptide substrate. Incucyte cell viability assays revealed varied bioactivities, with HEK293T cell growth rates ranging from 0.01 to 0.97, U2OS cell growth rates from -1.0 to 1.0, and human fibroblast cells showing growth rates of 0.64 and 0.93, indicating both inhibitory and stimulatory effects on different cell lines. The compound influences protein stability in a domain-specific manner, decreasing the thermal stability of domains like N44-E168, M626-G740, M1-L298, M26-R383, and G861-E979 while not altering the E122-S403 domain and increasing stability for domains like M1-K294, P449-E759, and M1-S360. Additionally, TC-O 9311 shows bioactivity in GPCR beta-arrestin recruitment assays across various targets such as GPR119, C5AR1, AGTR1, ADGRF1, CX3CR1, ADRA2A, FFAR4, S1PR1, GLP1R, ADRB2, FPR2, GPR35, and APLNR, with both agonistic and inhibitory effects, indicating a complex pharmacological profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).
Targets&IC50	GPR139:EC50 = 39 nM (in CHO-K1 cells)
Synonyms	TCO-9311, TC-O-9311, TC-O9311, TCO9311, TC-O 9311, TCO 9311

Chemical Properties

Molecular Weight	365.38
Formula	C₂₀H₁₉N₃O₄
Cas No.	444932-31-4
Smiles	COc1cc(OC)cc(c1)C(=O)NNC(=O)Nc1cccc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (342.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7369 mL	13.6844 mL	27.3688 mL	136.8438 mL
5 mM	0.5474 mL	2.7369 mL	5.4738 mL	27.3688 mL
10 mM	0.2737 mL	1.3684 mL	2.7369 mL	13.6844 mL
20 mM	0.1368 mL	0.6842 mL	1.3684 mL	6.8422 mL
50 mM	0.0547 mL	0.2737 mL	0.5474 mL	2.7369 mL
100 mM	0.0274 mL	0.1368 mL	0.2737 mL	1.3684 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc