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CDPPB
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Catalog No. T22641Cas No. 781652-57-1
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
CDPPB
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Purity: 99.16%
Catalog No. T22641Cas No. 781652-57-1
CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $38 | In Stock | In Stock | |
| 2 mg | $54 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $143 | In Stock | In Stock | |
| 25 mg | $259 | In Stock | In Stock | |
| 50 mg | $437 | In Stock | In Stock | |
| 100 mg | $653 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.16%
Appearance:Solid
Color:White
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Product Introduction
CDPPB AI Summary
CDPPB has been shown to potentiate the activity of human and rat metabotropic glutamate receptor 5 (mGluR5), demonstrating a fold potentiation of 4.0 in CHO cells overexpressing human mGluR5 and 4.3 towards rat mGluR5. It exhibits EC50 values of 10.0 nM for human mGluR5 and 20.0 nM for rat mGluR5 in transfected CHO cells. Additionally, its Ki value for human mGluR5 is 250.0 nM in a displacement assay. The compound shows positive allosteric modulation in calcium mobilization assays with EC50 values of 177.83 nM and 98.0 nM for human and rat mGluR5, respectively, in HEK293 cells. CDPPB demonstrates a LogD7.4 value of 3.82, suggesting favorable lipophilicity and membrane permeability.
Moreover, CDPPB exhibits antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at a 10 µM concentration, with inhibition rates of 0.24% and 0.53%, respectively. It also exhibits an inhibitory effect on the SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of 5.339%. Inhibition of human HDAC6 was observed with percentages of 69.99% and 12.17% using different peptide substrates.
Thermally, CDPPB affects various protein domain stabilities, increasing stability of domains such as S229-K512 and M626-G746, while decreasing stability of others like N44-E168 and M1-K294. Furthermore, the compound shows a range of effects on GPCR targets in beta-arrestin recruitment assays, inhibiting targets like FPR2 and ADRB2, while activating receptors such as C5AR1 and S1PR1. These diverse bioactivities suggest it may modulate multiple physiological processes regulated by these receptors..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CDPPB is a modulator of mGluR5 positive allosteric(with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5). |
| Targets&IC50 | mGluR5:27 nM (EC50) |
| Molecular Weight | 364.4 |
| Formula | C23H16N4O |
| Cas No. | 781652-57-1 |
| Smiles | O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)c1cccc(c1)C#N |
| Relative Density. | 1.203g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.65 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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