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Idazoxan hydrochloride

Name: Idazoxan hydrochloride
Brand: TargetMol
SKU: T0115
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0115Cas No. 79944-56-2

Alias RX 781094

Idazoxan hydrochloride (RX 781094) is a benzodioxane-linked imidazole. It has alpha-2 adrenoceptor antagonist activity.

Idazoxan hydrochloride

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Purity: 99.84%

Catalog No. T0115Alias RX 781094Cas No. 79944-56-2

Idazoxan hydrochloride (RX 781094) is a benzodioxane-linked imidazole. It has alpha-2 adrenoceptor antagonist activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	-	In Stock
5 mg	$44	-	In Stock
10 mg	$71	-	In Stock
25 mg	$135	-	In Stock
50 mg	$196	-	In Stock
100 mg	$296	-	In Stock
200 mg	$438	-	In Stock
1 mL x 10 mM (in DMSO)	$46	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Idazoxan hydrochloride AI Summary

Idazoxan hydrochloride exhibits a diverse range of bioactivities across various biological systems. It has a LogD value of 0.33 and shows significant antagonistic activity against the Alpha-2 adrenergic receptor with a Kd value of 15.85 nM, while also demonstrating agonistic activity against the Alpha-1 adrenergic receptor with a Kd value of 1584.89 nM. The compound displays selectivity with a ratio of 100.0 towards the Alpha-2 adrenergic receptor over the Alpha-1 receptor. Furthermore, in murine and rat assays, it shows alpha-2 adrenergic receptor agonist activity with a Kd value of 10.47 nM and alpha-1 adrenergic receptor agonist activity with a Kd value of 501.19 nM, respectively, suggesting a selectivity ratio of 50.0 in these models. In terms of antiplasmodial activity, Idazoxan hydrochloride effectively inhibits various strains of Plasmodium falciparum, with IC50 values ranging from 10,000.0 nM to 12,589.25 nM. The compound also affects the proliferation of different lines of Plasmodium falciparum and demonstrates multiple molecular modulations such as Lamin A splicing, JMJD2E inhibition, Tau fibril formation inhibition, and interactions with proteins and receptors like Neuropeptide S Receptor, Jumonji Domain Containing 2E, Histone Lysine Methyltransferase G9a, and BLM, among others. Idazoxan hydrochloride has demonstrated antiviral activity notably against SARS-CoV-2. It inhibits the viability of Vero E6 cells and Caco-2 cells infected with SARS-CoV-2, showing an inhibition index of 1.162 and an inhibition rate of 7.58% at 10 µM after 48 hours, respectively. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 14.22% at a concentration of 20 µM. However, the inhibitive effect on VERO-6 cells cytotoxicity is relatively lower at 0.37% inhibition rate. This multi-target activity underscores Idazoxan hydrochloride’s potential as a therapeutic agent across different disease areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Idazoxan hydrochloride (RX 781094) is a benzodioxane-linked imidazole. It has alpha-2 adrenoceptor antagonist activity.
Synonyms	RX 781094

Chemical Properties

Molecular Weight	240.69
Formula	C₁₁H₁₂N₂O₂·HCl
Cas No.	79944-56-2
Smiles	Cl.C1CN=C(N1)C1COC2=C(O1)C=CC=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (415.47 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1547 mL	20.7736 mL	41.5472 mL	207.7361 mL
5 mM	0.8309 mL	4.1547 mL	8.3094 mL	41.5472 mL
10 mM	0.4155 mL	2.0774 mL	4.1547 mL	20.7736 mL
20 mM	0.2077 mL	1.0387 mL	2.0774 mL	10.3868 mL
50 mM	0.0831 mL	0.4155 mL	0.8309 mL	4.1547 mL
100 mM	0.0415 mL	0.2077 mL	0.4155 mL	2.0774 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc