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GSK-LSD1 dihydrochloride

Name: GSK-LSD1 dihydrochloride
Brand: TargetMol
SKU: T2315
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)) Copy Product Info

🥰Excellent

Synonyms: GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)

Catalog No. T2315 Copy Product Info

Purity: 98.72%

🥰Excellent

GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a highly potent, specific, and irreversible LSD1 inhibitor (IC50 = 16 nM). By inhibiting LSD1-mediated epigenetic modifications, GSK-LSD1 dihydrochloride promotes differentiation and inhibits proliferation in cancer cells, demonstrating antitumor activity in various hematologic malignancies and certain solid tumor models. GSK-LSD1 dihydrochloride can be used in research in the fields of epigenetics, oncology, metabolism, and inflammation.

Cas No. 2102933-95-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$34	In Stock	In Stock
2 mg	$48	In Stock	In Stock
5 mg	$65	In Stock	In Stock
10 mg	$105	In Stock	In Stock
25 mg	$221	In Stock	In Stock
50 mg	$335	In Stock	In Stock
100 mg	$549	In Stock	In Stock
500 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.72%

Color:Yellow

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a highly potent, specific, and irreversible LSD1 inhibitor (IC50 = 16 nM). By inhibiting LSD1-mediated epigenetic modifications, GSK-LSD1 dihydrochloride promotes differentiation and inhibits proliferation in cancer cells, demonstrating antitumor activity in various hematologic malignancies and certain solid tumor models. GSK-LSD1 dihydrochloride can be used in research in the fields of epigenetics, oncology, metabolism, and inflammation.
Targets & IC50	LSD1:16 nM
In vitro	Methods: Cells derived from wild-type iPSCs were treated with 500 nM GSK-LSD1 dihydrochloride from day 8 to day 12 of differentiation (5 days total), and expression of the megakaryocyte marker CD42b and the myeloid marker CD86 was detected. Results: GSK-LSD1 dihydrochloride Long-term treatment resulted in a significant reduction in the proportion of CD42b-positive cells and an increase in CD86-positive cells, confirming that LSD1 inhibition impairs megakaryocyte differentiation and promotes a shift toward myeloid differentiation.[1]
In vivo	Methods: db/db mice (leptin receptor-deficient) and their leptin-competent controls (db/+) received intraperitoneal injections of GSK-LSD1 (500 μg/kg/day) once daily for 6 weeks. Results: GSK-LSD1 dihydrochloride treatment significantly reduced weight gain and food intake in obese mice, markedly decreased fasting blood glucose and insulin levels, and improved glucose tolerance and insulin sensitivity. No significant effects were observed in lean mice. [2]
Synonyms	GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)

Chemical Properties

Molecular Weight	289.24
Formula	C₁₄H₂₂Cl₂N₂
Cas No.	2102933-95-7
Smiles	Cl.Cl.C1[C@@H](NC2CCNCC2)[C@@H]1c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (86.43 mM), Sonication is recommended.

H2O: 50 mg/mL (172.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.91 mM), Sonication is recommended.

10% DMSO+90% Saline: 2.5 mg/mL (8.64 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.4573 mL	17.2867 mL	34.5734 mL	172.8668 mL
5 mM	0.6915 mL	3.4573 mL	6.9147 mL	34.5734 mL
10 mM	0.3457 mL	1.7287 mL	3.4573 mL	17.2867 mL
20 mM	0.1729 mL	0.8643 mL	1.7287 mL	8.6433 mL
50 mM	0.0691 mL	0.3457 mL	0.6915 mL	3.4573 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0346 mL	0.1729 mL	0.3457 mL	1.7287 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Monoamine OxidaseMAOLSD1InhibitorinhibitHistoneDemethylaseHistone DemethylaseGSK-LSD-1 dihydrochlorideGSK-LSD1 DihydrochlorideGSKLSD1 dihydrochlorideGSK-LSD1GSK LSD1 dihydrochloride

Related Tags: GSK-LSD1 dihydrochloride chemical structure | GSK-LSD1 dihydrochloride in vivo | GSK-LSD1 dihydrochloride in vitro | GSK-LSD1 dihydrochloride formula | GSK-LSD1 dihydrochloride molecular weight