Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxyphenisatine (Oxyphenisatin), along with related bisacodyl, sodium picosulfate, and phenolphthalein, isa precursor of oxyphenisatine, which has anticancer activity. Oxyphenisatine is often used as a laxative and can cause liver damage when used long-term.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 49.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Oxyphenisatine (Oxyphenisatin), along with related bisacodyl, sodium picosulfate, and phenolphthalein, isa precursor of oxyphenisatine, which has anticancer activity. Oxyphenisatine is often used as a laxative and can cause liver damage when used long-term. |
In vitro | Oxyphenisatin exhibits antiproliferative properties. Oxyphenisatin acetate (OXY, NSC 59687) functions as the pro-drug for oxyphenisatin. OXY suppresses the growth of breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC 50 =0.8, 0.6, 2.1, 1.8 μM). This impact is linked to specific inhibition of translation, accompanied by swift phosphorylation of the nutrient-sensing eukaryotic translation initiation factor 2α (eIF2α) kinases, GCN2, and PERK.[1] |
In vivo | Toxicity studies indicate that mice exhibit tolerance to IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. The administration of OXY at 300 mg/kg IP once daily for 10 days leads to noticeably smaller tumors from day 33 to day 52.[1] |
Synonyms | Oxyphenisatin |
Molecular Weight | 317.34 |
Formula | C20H15NO3 |
CAS No. | 125-13-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (283.6 mM)
You can also refer to dose conversion for different animals. More
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Oxyphenisatine 125-13-3 Oxyphenisatin inhibitor inhibit