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BAY-850

Name: BAY-850
Brand: TargetMol
SKU: T14510
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14510Cas No. 2099142-76-2

BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.

BAY-850

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Purity: 98%

Catalog No. T14510Cas No. 2099142-76-2

BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$44	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

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COA HPLC

Product Introduction

Bioactivity

Description	BAY-850 is a selective and potent inhibitor of adenosine triphosphatase family protein 2 (ATAD2) (IC50: 166 nM) that inhibits ovarian cancer growth and metastasis in in vitro and in vivo models.
Targets&IC50	ATAD2:166 nM, tetra-acetylated peptide:115 nM (Kd), tetra-acetylated peptide:157 nM
In vitro	In a TR-FRET assay, BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD, showing an IC50 of 166 nM. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM, respectively. The unprecedented isoform selectivity of BAY-850 suggests a mode of action different from those exhibited by canonical BD inhibitors[1].

Chemical Properties

Molecular Weight	654.24
Formula	C₃₈H₄₄ClN₅O₃
Cas No.	2099142-76-2
Smiles	COc1cc(Cl)c(cc1-c1ccc(CN[C@H](C)c2ccc(C)cc2)o1)C(=O)N[C@@H](CN[C@@H]1CC[C@H](N)CC1)Cc1ccc(cc1)C#N
Relative Density.	1.24 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <0.1 mg/mL (Insoluble)

DMSO: 50 mg/mL (76.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5285 mL	7.6425 mL	15.2849 mL	76.4246 mL
5 mM	0.3057 mL	1.5285 mL	3.0570 mL	15.2849 mL
10 mM	0.1528 mL	0.7642 mL	1.5285 mL	7.6425 mL
20 mM	0.0764 mL	0.3821 mL	0.7642 mL	3.8212 mL
50 mM	0.0306 mL	0.1528 mL	0.3057 mL	1.5285 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc