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KFM19

Name: KFM19
Brand: TargetMol
SKU: T15655
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15655Cas No. 133058-72-7

KFM19 is a potent and selective adenosine receptor (A1-receptor) antagonist (IC50 : 50 nM) for the study of neurological disorders.

KFM19

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Purity: 98.62%

Catalog No. T15655Cas No. 133058-72-7

KFM19 is a potent and selective adenosine receptor (A1-receptor) antagonist (IC50 : 50 nM) for the study of neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$95	In Stock	In Stock
10 mg	$138	In Stock	In Stock
25 mg	$260	In Stock	In Stock
50 mg	$383	In Stock	In Stock
100 mg	$545	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.62%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

KFM19 AI Summary

KFM19 demonstrates a high binding affinity towards the bovine Adenosine A1 receptor with a Ki value of 15.0 nM. It also binds to the Adenosine A2 receptor with a lower affinity, indicated by a Ki value of 2700.0 nM, yielding a binding ratio of A2 to A1 of 180.0. The compound's solubility is measured at 220.0 µg/mL in water and 200.0 µg/mL in saline. Additionally, KFM19 exhibits antagonistic activity in avoidance tests induced by Scopolamine and (R)-PIA in both rats and mice. It was also tested for locomotor activity at doses of 2.5 mg/kg and 10 mg/kg, showing increasing counts over a 120-minute period..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	KFM19 is a potent and selective adenosine receptor (A1-receptor) antagonist (IC50 : 50 nM) for the study of neurological disorders.
Targets&IC50	Adenosine receptor:50 nM

Chemical Properties

Molecular Weight	318.37
Formula	C₁₆H₂₂N₄O₃
Cas No.	133058-72-7
Smiles	CCCn1c2[nH]c(nc2c(=O)n(CCC)c1=O)C1CCC(=O)C1
Relative Density.	1.268g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (251.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1410 mL	15.7050 mL	31.4100 mL	157.0500 mL
5 mM	0.6282 mL	3.1410 mL	6.2820 mL	31.4100 mL
10 mM	0.3141 mL	1.5705 mL	3.1410 mL	15.7050 mL
20 mM	0.1570 mL	0.7852 mL	1.5705 mL	7.8525 mL
50 mM	0.0628 mL	0.3141 mL	0.6282 mL	3.1410 mL
100 mM	0.0314 mL	0.1570 mL	0.3141 mL	1.5705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc