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Urocortin, rat TFA (171543-83-2 free base)
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Catalog No. TP2159
Alias Urocortin, rat TFA, Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA
Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
Urocortin, rat TFA (171543-83-2 free base)
Urocortin, rat TFA (171543-83-2 free base)
😃Good
Catalog No. TP2159Alias Urocortin, rat TFA, Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA
Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 500 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1). |
| Targets&IC50 | CRF1 (human):ki： 13 nM , CRF2β (mouse):0.97 nM (ki), CRF2α (rat):1.5 nM (ki) |
| In vitro | In stably transfected Chinese hamster ovary cells, Urocortin, rat induces cAMP generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α, and mouse CRF2β, respectively [2]. |
| In vivo | Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat (i.c.v.). It has the potential of inducing anxiogenic behavior [3]. |
| Synonyms | Urocortin, rat TFA, Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA |
| Molecular Weight | 4821.28 |
| Formula | C208H339N62F3O66 |
| Relative Density. | 1.31g/cm3 |
| Sequence | H-Asp-Asp-Pro-Pro-Leu-Ser-lle-Asp-Leu-Thr- Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu- Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala- Glu-Gln-Asn-Arg-lle-lle-Phe-Asp-Ser-Val-NH2 |
| Sequence Short | DDPPLSDLTFHLLRTLLELARTQSQRERAEQNRFDSV |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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