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Anti-COMP Antibody-HRP (1M696) is a HRP-conjugated Mouse antibody targeting COMP. Anti-COMP Antibody-HRP (1M696) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $446 | 7-10 days |
Description | Anti-COMP Antibody-HRP (1M696) is a HRP-conjugated Mouse antibody targeting COMP. Anti-COMP Antibody-HRP (1M696) can be used in ELISA. |
Alias | THBS5, PSACH, MED, EPD1, EDM1, cartilage oligomeric matrix protein |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 1M696 |
Reactivity | Human |
Application | ELISA |
Recommended Dose | ELISA: 0.1-1 μg/ml |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human COMP (rhCOMP; TMPY-00725; NP_000086.2; Met 1-Ala 757). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas. |
Conjucates | HRP |
Others Formats | Unconjugated |
Antibody Types Available | 2 |
Immunogen | Recombinant Human COMP protein (TMPY-00725) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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