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Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2
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Catalog No. TMAB-10932
Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-MAP3K8 (Ser400). Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2
Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-10932
Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-MAP3K8 (Ser400). Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-MAP3K8 (Ser400). Anti-Phospho-MAP3K8 (Ser400) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Expressed in several normal tissues and human tumor-derived cell lines. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human MAP3K8/Tpl2 around the phosphorylation site of Ser400 |
| Antigen Species | Human |
| Gene Name | MAP3K8 |
| Gene ID | |
| Protein Name | Mitogen-activated protein kinase kinase kinase 8 |
| Uniprot ID | |
| Function | Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein. |
| Molecular Weight | Theoretical: 53 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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