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PU02

Name: PU02
Brand: TargetMol
SKU: T8445
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8445Cas No. 313984-77-9

Alias PU-02, 6-[(1-Naphthalenylmethyl)thio]-9H-purine

PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.

PU02

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Purity: 99.35%

Catalog No. T8445Alias PU-02, 6-[(1-Naphthalenylmethyl)thio]-9H-purineCas No. 313984-77-9

PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$58	In Stock
25 mg	$113	In Stock
50 mg	$208	In Stock
100 mg	$333	In Stock
200 mg	$479	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock

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Batch Information

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Purity:99.35%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.
Targets&IC50	5-HT3AB:0.73 μM (IC50), 5-HT3A receptor:0.36 μM (IC50)
Synonyms	PU-02, 6-[(1-Naphthalenylmethyl)thio]-9H-purine

Chemical Properties

Molecular Weight	292.36
Formula	C₁₆H₁₂N₄S
Cas No.	313984-77-9
Smiles	C(Sc1ncnc2nc[nH]c12)c1cccc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (102.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4204 mL	17.1022 mL	34.2044 mL	171.0220 mL
5 mM	0.6841 mL	3.4204 mL	6.8409 mL	34.2044 mL
10 mM	0.3420 mL	1.7102 mL	3.4204 mL	17.1022 mL
20 mM	0.1710 mL	0.8551 mL	1.7102 mL	8.5511 mL
50 mM	0.0684 mL	0.3420 mL	0.6841 mL	3.4204 mL
100 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7102 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc