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Anti-IL-1R1 Antibody (4O465)
😃Good
Catalog No. TMAH-00618
Alias P80, interleukin 1 receptor, type I, IL-1R-α, IL-1R-alpha, IL1RA, IL-1R1, IL1R, IL-1 RI, D2S1473, CD121A
Anti-IL-1R1 Antibody (4O465) is an antibody targeting IL-1R1. Anti-IL-1R1 Antibody (4O465) can be used in ELISA,FCM.
Anti-IL-1R1 Antibody (4O465)
Anti-IL-1R1 Antibody (4O465)
😃Good
Catalog No. TMAH-00618Alias P80, interleukin 1 receptor, type I, IL-1R-α, IL-1R-alpha, IL1RA, IL-1R1, IL1R, IL-1 RI, D2S1473, CD121A
Anti-IL-1R1 Antibody (4O465) is an antibody targeting IL-1R1. Anti-IL-1R1 Antibody (4O465) can be used in ELISA,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-1R1 Antibody (4O465) is an antibody targeting IL-1R1. Anti-IL-1R1 Antibody (4O465) can be used in ELISA,FCM. |
| Synonyms | P80, interleukin 1 receptor, type I, IL-1R-α, IL-1R-alpha, IL1RA, IL-1R1, IL1R, IL-1 RI, D2S1473, CD121A |
| Ig Type | Mouse IgG2a |
| Clone | 4O465 |
| Reactivity | Human |
| Verified Activity | Overlay Peak curve showing NIH/3T3 cells surface stained with TMAH-00618 (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Cell membrane. Secreted. |
| Tissue Specificity | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human IL1R1 Protein |
| Antigen Species | Human |
| Gene Name | IL1R1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cardiovascular, Immunology, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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