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Anti-CD6 Antibody-APC (3M203)
🥰Excellent
Catalog No. TMAY-03813A
Anti-CD6 Antibody-APC (3M203) is a APC-conjugated Mouse antibody targeting CD6. Anti-CD6 Antibody-APC (3M203) can be used in FCM.
Anti-CD6 Antibody-APC (3M203)
Anti-CD6 Antibody-APC (3M203)
🥰Excellent
Catalog No. TMAY-03813A
Anti-CD6 Antibody-APC (3M203) is a APC-conjugated Mouse antibody targeting CD6. Anti-CD6 Antibody-APC (3M203) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD6 Antibody-APC (3M203) is a APC-conjugated Mouse antibody targeting CD6. Anti-CD6 Antibody-APC (3M203) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 3M203 |
| Reactivity | Rat |
| Verified Activity | Flow cytometric analysis of Rat CD6 expression on SD rat splenocytes. Cells were stained with APC-conjugated anti-Rat CD6. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD6 / Cluster of Differentiation 6 (rR CD6 / Cluster of Differentiation 6; TMPY-03731; Q812A4; Met1-Asn396) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse. |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Rat CD6 / Cluster of Differentiation 6 Protein (TMPY-03731) |
| Antigen Species | Rat |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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