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BRD4/CK2-IN-1
🥰Excellent
Catalog No. T63991Cas No. 2756851-99-5
BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.
BRD4/CK2-IN-1
🥰Excellent
Purity: 99.02%
Catalog No. T63991Cas No. 2756851-99-5
BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $84 | - | In Stock | |
| 5 mg | $198 | - | In Stock | |
| 10 mg | $313 | - | In Stock | |
| 25 mg | $619 | - | In Stock | |
| 50 mg | $987 | - | In Stock | |
| 100 mg | $1,490 | - | In Stock | |
| 200 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.02%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research. |
| Targets&IC50 | BRD4:180 nM, CK2:230 nM |
| In vitro | BRD4/CK2-IN-1 showed significant inhibitory activity against BRD4 (IC50 = 180 nM). BRD4/ CK2-in-1 showed significant inhibitory activity against CK2 (IC50 = 230 nM). BRD4/ CK2-in-1 induces TNBC cell death by targeting BRD4 and CK2. BRD4/ CK2-in-1 can bind to BRD4 and CK2 IN cells and inhibit BRD4 and CK2-regulated proliferation pathways, but has no significant effect on the protein levels of BRD4 and CK2. [1] |
| In vivo | In MDA-MB-468 and MDA-MB-231 xenograft tumor models, BRD4/CK2-IN-1 (25 mg/kg and 50 mg/kg) was administered intravenously and orally to inhibit tumor growth in a dose-dependent manner. [1] |
| Molecular Weight | 564.03 |
| Formula | C29H30ClN5O5 |
| Cas No. | 2756851-99-5 |
| Smiles | O=C1N=C(NC=2C=C(OC)C=C(OC)C12)C=3C=CC(OCC(=O)NC4=CC=C(C(Cl)=C4)N5CCN(C)CC5)=CC3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (28.37 mM), when pH is adjusted to 3 with HCl, sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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