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BRD4/CK2-IN-1
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Catalog No. T63991Cas No. 2756851-99-5
BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.
BRD4/CK2-IN-1
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Purity: 99.02%
Catalog No. T63991Cas No. 2756851-99-5
BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $84 | - | In Stock | |
| 5 mg | $198 | - | In Stock | |
| 10 mg | $313 | - | In Stock | |
| 25 mg | $619 | - | In Stock | |
| 50 mg | $987 | - | In Stock | |
| 100 mg | $1,490 | - | In Stock | |
| 200 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.02%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research. |
| Targets&IC50 | CK2:230 nM, BRD4:180 nM |
| In vitro | BRD4/CK2-IN-1 showed significant inhibitory activity against BRD4 (IC50 = 180 nM). BRD4/ CK2-in-1 showed significant inhibitory activity against CK2 (IC50 = 230 nM). BRD4/ CK2-in-1 induces TNBC cell death by targeting BRD4 and CK2. BRD4/ CK2-in-1 can bind to BRD4 and CK2 IN cells and inhibit BRD4 and CK2-regulated proliferation pathways, but has no significant effect on the protein levels of BRD4 and CK2. [1] |
| In vivo | In MDA-MB-468 and MDA-MB-231 xenograft tumor models, BRD4/CK2-IN-1 (25 mg/kg and 50 mg/kg) was administered intravenously and orally to inhibit tumor growth in a dose-dependent manner. [1] |
| Molecular Weight | 564.03 |
| Formula | C29H30ClN5O5 |
| Cas No. | 2756851-99-5 |
| Smiles | O=C1N=C(NC=2C=C(OC)C=C(OC)C12)C=3C=CC(OCC(=O)NC4=CC=C(C(Cl)=C4)N5CCN(C)CC5)=CC3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (28.37 mM), when pH is adjusted to 3 with HCl, sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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