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DOV-216,303 Free Base

Name: DOV-216,303 Free Base
Brand: TargetMol
SKU: T11087
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11087Cas No. 66504-40-3

Alias DOV-216303

DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.

DOV-216,303 Free Base

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Purity: 96.7%

Catalog No. T11087Alias DOV-216303Cas No. 66504-40-3

DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	-	In Stock
5 mg	$60	-	In Stock
10 mg	$98	-	In Stock
25 mg	$162	-	In Stock
50 mg	$238	-	In Stock
100 mg	$357	-	In Stock
1 mL x 10 mM (in DMSO)	$62	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.7%

Appearance:Liquid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.
Targets&IC50	5-HT:14 nM , Norepinephrine:20 nM , Dopamine:78 nM
In vivo	In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels[2].
Synonyms	DOV-216303

Chemical Properties

Molecular Weight	228.12
Formula	C₁₁H₁₁Cl₂N
Cas No.	66504-40-3
Smiles	Clc1ccc(cc1Cl)C12CC1CNC2
Relative Density.	1.371 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (547.96 mM), Sonication is recommended.

Ethanol: 95 mg/mL (416.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (17.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3837 mL	21.9183 mL	43.8366 mL	219.1829 mL
5 mM	0.8767 mL	4.3837 mL	8.7673 mL	43.8366 mL
10 mM	0.4384 mL	2.1918 mL	4.3837 mL	21.9183 mL
20 mM	0.2192 mL	1.0959 mL	2.1918 mL	10.9591 mL
50 mM	0.0877 mL	0.4384 mL	0.8767 mL	4.3837 mL
100 mM	0.0438 mL	0.2192 mL	0.4384 mL	2.1918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc