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DOV-216,303 Free Base

Name: DOV-216,303 Free Base
Brand: TargetMol
SKU: T11087
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11087Cas No. 66504-40-3

Alias DOV-216303

DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.

DOV-216,303 Free Base

🥰Excellent

Purity: 96.7%

Catalog No. T11087Alias DOV-216303Cas No. 66504-40-3

DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	-	In Stock
5 mg	$60	-	In Stock
10 mg	$98	-	In Stock
25 mg	$162	-	In Stock
50 mg	$238	-	In Stock
100 mg	$357	-	In Stock
1 mL x 10 mM (in DMSO)	$62	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:96.7%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DOV-216,303 Free Base (DOV-216303) is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.
Targets&IC50	Norepinephrine:20 nM , 5-HT:14 nM , Dopamine:78 nM
In vivo	In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels[2].
Synonyms	DOV-216303

Chemical Properties

Molecular Weight	228.12
Formula	C₁₁H₁₁Cl₂N
Cas No.	66504-40-3
Smiles	Clc1ccc(cc1Cl)C12CC1CNC2
Relative Density.	1.371 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (547.96 mM), Sonication is recommended.

Ethanol: 95 mg/mL (416.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (17.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3837 mL	21.9183 mL	43.8366 mL	219.1829 mL
5 mM	0.8767 mL	4.3837 mL	8.7673 mL	43.8366 mL
10 mM	0.4384 mL	2.1918 mL	4.3837 mL	21.9183 mL
20 mM	0.2192 mL	1.0959 mL	2.1918 mL	10.9591 mL
50 mM	0.0877 mL	0.4384 mL	0.8767 mL	4.3837 mL
100 mM	0.0438 mL	0.2192 mL	0.4384 mL	2.1918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc