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Cyclosporin A-Derivative 2

Name: Cyclosporin A-Derivative 2
Brand: TargetMol
SKU: TP1387
Rating: 4.5 (1 reviews)

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Catalog No. TP1387Cas No. 156047-45-9

Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin.

Cyclosporin A-Derivative 2

😃Good

Catalog No. TP1387Cas No. 156047-45-9

Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$121	Inquiry	Inquiry
5 mg	$288	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin.

Chemical Properties

Molecular Weight	1149.51
Formula	C₅₈H₁₀₄N₁₀O₁₃
Cas No.	156047-45-9
Smiles	[C@@H]([C@@H]([C@@H](C/C=C/C)C)OC(C)=O)(N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@H](C(C)C)N)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)[C@@H](C)C)=O)C)C(N[C@H](C(N(CC(OC)=O)C)=O)CC)=O
Relative Density.	1.105 g/cm3 (Predicted)
Sequence Short	VLA-{d-Ala}-LLV-{Aaa}-{Abu}-{Sar}

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Cyclosporin A-Derivative 2Cyclosporin ADerivative 2Cyclosporin A Derivative 2