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YM-58790

Name: YM-58790
Brand: TargetMol
SKU: T72038
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72038Cas No. 168830-70-4

Alias YM-58790 free base

YM-58790 free base is a potent mAChR antagonist that inhibits M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively. It inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.

YM-58790

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Purity: 99.87%

Catalog No. T72038Alias YM-58790 free baseCas No. 168830-70-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$62	In Stock	In Stock
5 mg	$135	In Stock	In Stock
10 mg	$217	In Stock	In Stock
25 mg	$415	In Stock	In Stock
50 mg	$593	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	YM-58790 free base is a potent mAChR antagonist that inhibits M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively. It inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.
Targets&IC50	M3 mAChR:15 nM (Ki), M1 mAChR:28 nM (Ki), M2 mAChR:260 nM (Ki)
In vitro	YM-58790 free base (compound 18b) (0-1 μM) potently inhibits urinary bladder contraction with minimal impact on bradycardia. In vitro, YM-58790 selectively antagonizes urinary bladder contraction without significantly affecting salivary secretion. [1]
In vivo	YM-58790 free base (3 mg/kg, i.v.) exhibits no impact on oxotremorine-induced tremor in mice.[1] At 6.0 mg/kg, i.v., YM-58790 free base shows limited M1 and M2 antagonistic effects on McN-A343-induced pressor response in pithed rats but demonstrates robust M3 antagonism, with an ED30 value of 0.36 mg/kg and an ID50 value of 2.4 mg/kg.[1] Additionally, YM-58790 free base exhibits strong inhibitory activity on bladder pressure during reflexly-evoked rhythmic contractions in rats.[1]
Synonyms	YM-58790 free base

Chemical Properties

Molecular Weight	429.55
Formula	C₂₇H₃₁N₃O₂
Cas No.	168830-70-4
Smiles	C(NC(OC1CCN(CC2=CC=C(NC)C=C2)CC1)=O)(C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.18 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (139.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3280 mL	11.6401 mL	23.2802 mL	116.4009 mL
5 mM	0.4656 mL	2.3280 mL	4.6560 mL	23.2802 mL
10 mM	0.2328 mL	1.1640 mL	2.3280 mL	11.6401 mL
20 mM	0.1164 mL	0.5820 mL	1.1640 mL	5.8200 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3280 mL
100 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc