Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 323.00 | |
10 mg | In stock | $ 516.00 | |
25 mg | In stock | $ 990.00 | |
50 mg | In stock | $ 1,680.00 | |
100 mg | In stock | $ 2,698.00 | |
500 mg | In stock | $ 3,780.00 |
Description | YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization. |
Targets&IC50 | M3 mAChR:15 nM (Ki), M1 mAChR:28 nM (Ki), M2 mAChR:260 nM (Ki) |
In vitro | YM-58790 free base (compound 18b) (0-1 μM) exerts a potent inhibitory effect on urinary bladder contraction while having minimal impact on bradycardia. In vitro, YM-58790 demonstrates selective antagonism between urinary bladder contraction and salivary secretion.[1] |
In vivo |
YM-58790 free base (3 mg/kg, i.v.) exhibits no impact on oxotremorine-induced tremor in mice.[1] YM-58790 free base (6.0 mg/kg; i.v.) exhibits limited M1 and M2 antagonistic effects in vivo on McN-A343-induced pressor response in pithed rats. However, it demonstrates robust efficacy in M3 antagonism, with an ED30 value of 0.36 mg/kg and an ID50 value of 2.4 mg/kg.[1] YM-58790 free base demonstrates robust inhibitory activity on bladder pressure during reflexly-evoked rhythmic contractions in rats.[1] |
Synonyms | YM-58790 free base |
Molecular Weight | 429.55 |
Formula | C27H31N3O2 |
CAS No. | 168830-70-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (139.68 mM)
You can also refer to dose conversion for different animals. More
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YM-58790 168830-70-4 Neuroscience AChR YM-58790 free base YM 58790 YM58790 inhibitor inhibit