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Anti-IFNAR1 Antibody (4A488)
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Catalog No. TMAY-03308
Alias interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1
Anti-IFNAR1 Antibody (4A488) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (4A488) can be used in ICC/IF.
Anti-IFNAR1 Antibody (4A488)
Anti-IFNAR1 Antibody (4A488)
😃Good
Catalog No. TMAY-03308Alias interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1
Anti-IFNAR1 Antibody (4A488) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (4A488) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $92 | 7-10 days | |
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ICC/IF Reactivity: Mouse |
| Alias | interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1 |
| Ig Type | Rabbit IgG |
| Clone | 4A488 |
| Reactivity | Mouse |
| Verified Activity | Immunofluorescence staining of mouse IFNAR1 in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse IFNAR1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 594-conjugated Goat Anti-rabbit IgG secondary antibody (red) and counterstained with DAPI (blue). |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNAR1 (rM IFNAR1; TMPY-01489; NP_034638.2; Met1-Thr429). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse IFNAR1 Protein (TMPY-01489) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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