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Anti-IFNAR1 Antibody (4A488)

😃Good
Catalog No. TMAY-03308
Alias interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1

Anti-IFNAR1 Antibody (4A488) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (4A488) can be used in ICC/IF.

Anti-IFNAR1 Antibody (4A488)

Anti-IFNAR1 Antibody (4A488)

😃Good
Catalog No. TMAY-03308Alias interferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1
Anti-IFNAR1 Antibody (4A488) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (4A488) can be used in ICC/IF.
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$268 7-10 days
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Product Introduction

Bioactivity
Description
Anti-IFNAR1 Antibody (4A488) is a Rabbit antibody targeting IFNAR1. Anti-IFNAR1 Antibody (4A488) can be used in ICC/IF.
Aliasinterferon (α, β and ω) receptor 1, interferon (α, β and Ω) receptor 1, interferon (alpha, beta and omega) receptor 1
Ig Type
Monoclonal Rabbit IgG
Clone
4A488
Reactivity
Mouse
Verified Activity
Immunofluorescence staining of mouse IFNAR1 in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse IFNAR1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 594-conjugated Goat Anti-rabbit IgG secondary antibody (red) and counterstained with DAPI (blue).
Application
ICC/IF
Recommended Dose
ICC-IF: 1:20-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNAR1 (rM IFNAR1; TMPY-01489; NP_034638.2; Met1-Thr429).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundInterferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Mouse IFNAR1 Protein (TMPY-01489)
Antigen Species
Mouse
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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