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Anti-FGFR2 Antibody (8Z855)
😃Good
Catalog No. TMAY-01226
Alias TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS
Anti-FGFR2 Antibody (8Z855) is a Mouse antibody targeting FGFR2. Anti-FGFR2 Antibody (8Z855) can be used in ELISA(Det).
Anti-FGFR2 Antibody (8Z855)
Anti-FGFR2 Antibody (8Z855)
😃Good
Catalog No. TMAY-01226Alias TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS
Anti-FGFR2 Antibody (8Z855) is a Mouse antibody targeting FGFR2. Anti-FGFR2 Antibody (8Z855) can be used in ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $69 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Mouse Monoclonal Application: ELISA(Det) Reactivity: Human |
| Alias | TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS |
| Ig Type | Mouse IgG1 |
| Clone | 8Z855 |
| Reactivity | Human |
| Application | ELISA(Det) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | HRP |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human FGFR2 Protein (TMPY-01228) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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