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Dual GO/LDHA-IN-1
Catalog No. T215128 Copy Product Info
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Dual GO/LDHA-IN-1 is an orally effective dual-target inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), with Ki values of 390 nM and 40 nM, respectively. It decreases liver LDHA levels, urinary oxalate excretion, and renal calcium oxalate crystal deposition. Dual GO/LDHA-IN-1 is applicable for research in primary hyperoxaluria type 1.
Dual GO/LDHA-IN-1
Copy Product Info🥰Excellent
Catalog No. T215128
Dual GO/LDHA-IN-1 is an orally effective dual-target inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), with Ki values of 390 nM and 40 nM, respectively. It decreases liver LDHA levels, urinary oxalate excretion, and renal calcium oxalate crystal deposition. Dual GO/LDHA-IN-1 is applicable for research in primary hyperoxaluria type 1.
Dual GO/LDHA-IN-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Dual GO/LDHA-IN-1 is an orally effective dual-target inhibitor of glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), with Ki values of 390 nM and 40 nM, respectively. It decreases liver LDHA levels, urinary oxalate excretion, and renal calcium oxalate crystal deposition. Dual GO/LDHA-IN-1 is applicable for research in primary hyperoxaluria type 1. |
| In vitro | Dual GO/LDHA-IN-1 (Compound 2) effectively inhibits hGO and hLDHA, with higher selectivity for hLDHA over hLDHB (hGO IC₅₀ of 1.1 μM, hGO Kᵢ of 0.39 μM; hLDHA IC₅₀ of 0.05 μM, hLDHA Kᵢ of 0.04 μM; hLDHB Kᵢ of 1.7 μM). When used at concentrations of 10-50 μM for 24 hours, it reduces intracellular oxalate levels without cytotoxicity. Additionally, at concentrations of 2-50 μM for 24 hours, Dual GO/LDHA-IN-1 induces LDHA degradation via the autophagy-lysosome pathway. |
| In vivo | Dual GO/LDHA-IN-1 (20 mg/kg; oral administration; once daily; for 10 consecutive days) reduces liver LDHA levels, urinary oxalate concentrations, and renal calcium oxalate crystal deposition in Agxt −/− mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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