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Ameltolide

Name: Ameltolide
Brand: TargetMol
SKU: T23717
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23717Cas No. 787-93-9

Ameltolide is an anticonvulsant agent. It has been shown to be effective at inhibiting seizures in animal models.

Ameltolide

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Purity: 98.82%

Catalog No. T23717Cas No. 787-93-9

Ameltolide is an anticonvulsant agent. It has been shown to be effective at inhibiting seizures in animal models.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	-	In Stock
50 mg	$31	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.82%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Ameltolide AI Summary

Ameltolide exhibits a range of bioactivities, including significant anticonvulsant and antiviral properties. In various anticonvulsant assays, Ameltolide demonstrates its effectiveness. In rats, it has an ED50 of 135.0 µmol/kg in a MES test when dosed orally and an IC50 value of 970.0 nM in a [3H]batrachotoxinin-A-20-alpha-benzoate-binding test. In mice, it shows a peak anticonvulsant effect 0.5 hours after oral dosing, with an ED50 of 1.4 mg/kg in the maximal electroshock assay and a protective index (PI) of 13.0, indicating a considerable safety margin. Additionally, it has been shown to affect ataxia with an ED50 of 23.0 mg/kg and can increase hexobarbital-induced sleeping time in a dose-dependent manner. Moreover, in mice, the compound has a toxic dose (TD50) of 15.01 mg/kg, an ED50 of 2.6 mg/kg in maximal electric seizures, and a protective index of 5.77. In terms of antiviral activity, Ameltolide exhibits inhibitory activity against SARS-CoV-2, showing a 38.81% inhibition of virus-induced cytotoxicity in Caco-2 cells at a 10 µM concentration after 48 hours. It also demonstrates 20.21% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM concentration. Additionally, it inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours exposure. Ameltolide also shows inhibitory effects in enzymatic assays of human HDAC6, with 7.12% inhibition using a commercial peptide substrate and 7.08% using a custom peptide substrate, suggesting potential for further exploration in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Ameltolide is an anticonvulsant agent. It has been shown to be effective at inhibiting seizures in animal models.

Chemical Properties

Molecular Weight	240.3
Formula	C₁₅H₁₆N₂O
Cas No.	787-93-9
Smiles	Cc1cccc(C)c1NC(=O)c1ccc(N)cc1
Relative Density.	1.182g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (187.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1615 mL	20.8073 mL	41.6146 mL	208.0732 mL
5 mM	0.8323 mL	4.1615 mL	8.3229 mL	41.6146 mL
10 mM	0.4161 mL	2.0807 mL	4.1615 mL	20.8073 mL
20 mM	0.2081 mL	1.0404 mL	2.0807 mL	10.4037 mL
50 mM	0.0832 mL	0.4161 mL	0.8323 mL	4.1615 mL
100 mM	0.0416 mL	0.2081 mL	0.4161 mL	2.0807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc