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BDP FL DBCO

Name: BDP FL DBCO
Brand: TargetMol
SKU: T14516
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14516Cas No. 2093197-94-3

BDP FL DBCO is a cleavable linker molecule critical for antibody-drug conjugate (ADC) synthesis. BDP FL DBCO enables the covalent attachment of cytotoxic drugs to antibodies, ensuring targeted delivery to cells or proteins, and the cleavable nature facilitates controlled drug release, optimizing the pharmacodynamic effectiveness of ADCs in oncology studies.

BDP FL DBCO

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Purity: 99.14%

Catalog No. T14516Cas No. 2093197-94-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	-	In Stock
5 mg	$162	-	In Stock
10 mg	$245	-	In Stock
25 mg	$493	-	In Stock
50 mg	$719	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.14%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BDP FL DBCO is a cleavable linker molecule critical for antibody-drug conjugate (ADC) synthesis. BDP FL DBCO enables the covalent attachment of cytotoxic drugs to antibodies, ensuring targeted delivery to cells or proteins, and the cleavable nature facilitates controlled drug release, optimizing the pharmacodynamic effectiveness of ADCs in oncology studies.
In vitro	The BDP FL DBCO molecule contains a DBCO (dibenzocyclooctyne) group, which can undergo copper-free click chemistry reactions with azides. Its excitation wavelength (λex) and emission wavelength (λem) are 503 nm and 512 nm, respectively [1].

Chemical Properties

Molecular Weight	550.41
Formula	C₃₂H₂₉BF₂N₄O₂
Cas No.	2093197-94-3
Smiles	O=C(NCCC(N1C2=C(C=CC=C2)C#CC3=C(C=CC=C3)C1)=O)CCC4=CC=C5C=C6C(C)=CC(C)=[N]6B(N54)(F)F
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (181.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8168 mL	9.0841 mL	18.1683 mL	90.8414 mL
5 mM	0.3634 mL	1.8168 mL	3.6337 mL	18.1683 mL
10 mM	0.1817 mL	0.9084 mL	1.8168 mL	9.0841 mL
20 mM	0.0908 mL	0.4542 mL	0.9084 mL	4.5421 mL
50 mM	0.0363 mL	0.1817 mL	0.3634 mL	1.8168 mL
100 mM	0.0182 mL	0.0908 mL	0.1817 mL	0.9084 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc