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Enpp/Carbonic anhydrase-IN-2

Name: Enpp/Carbonic anhydrase-IN-2
Brand: TargetMol
SKU: T77631
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77631Cas No. 2883495-39-2

Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.

Enpp/Carbonic anhydrase-IN-2

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Purity: 99.46%

Catalog No. T77631Cas No. 2883495-39-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
5 mg	$97	-	In Stock
10 mg	$156	-	In Stock
25 mg	$263	-	In Stock
50 mg	$375	-	In Stock
100 mg	$512	-	In Stock
200 mg	$690	-	In Stock
1 mL x 10 mM (in DMSO)	$103	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.46%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
Targets&IC50	CA XII:0.68 μM, NPP3:0.74 μM, CA IX:0.33 μM, NPP2:1.07 μM, NPP1:1.13 μM
In vitro	Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) exhibits low cytotoxicity against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s > 50 µM.[1] Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits the growth of various cancer cells, showing IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, and 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, and T-47D cells, respectively.[1] Additionally, Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner in K-562 cells.[1]

Chemical Properties

Molecular Weight	429.5
Formula	C₂₃H₂₄FNO₄S
Cas No.	2883495-39-2
Smiles	C(NC1=CC=C(OS(=O)(=O)C2=CC=C(F)C=C2)C=C1)(=O)C34CC5CC(C3)CC(C4)C5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (93.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3283 mL	11.6414 mL	23.2829 mL	116.4144 mL
5 mM	0.4657 mL	2.3283 mL	4.6566 mL	23.2829 mL
10 mM	0.2328 mL	1.1641 mL	2.3283 mL	11.6414 mL
20 mM	0.1164 mL	0.5821 mL	1.1641 mL	5.8207 mL
50 mM	0.0466 mL	0.2328 mL	0.4657 mL	2.3283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc