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Enpp/Carbonic anhydrase-IN-2

Catalog No. T77631 CAS 2883495-39-2

Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.

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Enpp/Carbonic anhydrase-IN-2 Chemical Structure

Enpp/Carbonic anhydrase-IN-2, CAS 2883495-39-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 93.00
5 mg	In stock	$ 230.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 626.00
50 mg	In stock	$ 892.00
100 mg	In stock	$ 1,220.00
500 mg	In stock	$ 2,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 245.00

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Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
Targets&IC50	CA IX:0.33 μM, CA XII:0.68 μM, NPP1:1.13 μM, NPP2:1.07 μM, NPP3:0.74 μM
In vitro	Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-2 µM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM.[1] Enpp/Carbonic anhydrase-IN-2 (0-100 µM) inhibits some cancer cells growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 µM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.[1] Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 µM) induces apoptosis in a dose-dependent manner at K-562 cells.[1]

Molecular Weight	429.5
Formula	C23H24FNO4S
CAS No.	2883495-39-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42.95 mg/mL (100 mM), Sonication is recommended.

References and Literature

1. Shahin AI, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. Eur J Med Chem. 2023 Jan 15;246:114958.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Enpp/Carbonic anhydrase-IN-2 2883495-39-2 Apoptosis Metabolism PDE Carbonic Anhydrase Enpp/Carbonic anhydraseIN2 inhibitor inhibit

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