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Kainic acid

Name: Kainic acid
Brand: TargetMol
SKU: T15643
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15643Cas No. 487-79-6

Kainic acid is an excitatory amino acid receptor agonist (EC50=16.2 μM). Kainic acid is an effective excitatory toxic agent. Kainic acid induces epileptic seizures.

Kainic acid

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Purity: 98.47%

Catalog No. T15643Cas No. 487-79-6

Kainic acid is an excitatory amino acid receptor agonist (EC50=16.2 μM). Kainic acid is an effective excitatory toxic agent. Kainic acid induces epileptic seizures.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	Preferential	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.47%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Kainic acid is an excitatory amino acid receptor agonist (EC50=16.2 μM). Kainic acid is an effective excitatory toxic agent. Kainic acid induces epileptic seizures.
Targets&IC50	Neuron:17.3 μM (EC50), Glutamate receptor 6 (HEK293 cells):0.7 μM (EC50), Glutamate receptor 5 (HEK293 cells):16.2 μM (EC50)
In vitro	METHODS: After the NSC-34 mouse motor neuron cell line was treated with Kainic acid (0.1 mM, 0.5 mM, 1 mM) for 24 and 48 hours, the cell viability was detected by the MTT method. RESULTS: Kainic acid induced excitotoxic injury, with an IC50 value of approximately 0.5 mM. [1]
In vivo	METHODS: To study the effect of Kainic acid on epileptic seizures, Kainic acid (30 mg/kg) was intraperitoneally injected into juvenile (20 mg/kg) or adult (30 mg/kg) male Slack+/+ and Slack−/− mice. RESULTS: After injection of 30 mg/kg of Kainic acid, grade 3 or above epileptic seizures occurred in mice within 20 minutes. Different mouse strains have different sensitivities to Kainic acid. For example, Slack - / - mice are more prone to severe epileptic seizures and status epilepticus (SE), and have a higher mortality rate than Slack+/+ mice. [2]

Chemical Properties

Molecular Weight	213.23
Formula	C₁₀H₁₅NO₄
Cas No.	487-79-6
Smiles	CC(=C)[C@H]1CNC([C@H]1CC(O)=O)C(O)=O
Relative Density.	1.2177 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (234.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (11.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.6898 mL	23.4489 mL	46.8977 mL	234.4886 mL
5 mM	0.9380 mL	4.6898 mL	9.3795 mL	46.8977 mL
10 mM	0.4690 mL	2.3449 mL	4.6898 mL	23.4489 mL
20 mM	0.2345 mL	1.1724 mL	2.3449 mL	11.7244 mL
50 mM	0.0938 mL	0.4690 mL	0.9380 mL	4.6898 mL
100 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3449 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc