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Anti-Laminin alpha 1 Polyclonal Antibody

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Catalog No. TMAB-08206

Anti-Laminin alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Laminin alpha 1. Anti-Laminin alpha 1 Polyclonal Antibody can be used in WB.

Anti-Laminin alpha 1 Polyclonal Antibody

Anti-Laminin alpha 1 Polyclonal Antibody

😃Good
Catalog No. TMAB-08206
Anti-Laminin alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Laminin alpha 1. Anti-Laminin alpha 1 Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Laminin alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Laminin alpha 1. Anti-Laminin alpha 1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted > extracellular space > extracellular matrix > basement membrane.
Tissue SpecificityBroadly expressed in: skin, heart, lung, and the reproductive tracts.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Laminin alpha 1
Antigen Species
Human
Gene Name
LAMA1
Gene ID
Protein Name
Laminin subunit alpha-1
Uniprot ID
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
Chemical Properties
Molecular WeightTheoretical: 337 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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