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α-​Chaconine

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Catalog No. TN1374Cas No. 20562-03-2
Alias alpha-Chaconine

Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects.

α-​Chaconine
Other Forms of α-​Chaconine:
α-Chaconine (Standard)TMSM-226120562-03-2
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α-​Chaconine

😃Good
Catalog No. TN1374Alias alpha-ChaconineCas No. 20562-03-2
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$1,3507-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects.
In vitro
This study confirmed their synergistic cytotoxic effects on C6 rat glioma cells by three different cell viability tests, namely WST-1 (water-soluble tetrazolium) assay sensitive to intracellular NADH concentration, menadione-catalysed chemiluminescent assay depending on both NAD(P)H concentration and NAD(P)H:quinone reductase activity, and LDH (lactate dehydrogenase) assay sensitive to the release of LDH from damaged cells. The maximum cytotoxic effect was observed at a ratio of 1:1 between α±-solanine and alpha-Chaconine at micromolar concentrations.
Synonymsalpha-Chaconine
Chemical Properties
Molecular Weight852.06
FormulaC45H73NO14
Cas No.20562-03-2
Smiles[H][C@]12CC[C@H](C)CN1[C@@]1([H])C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@@H]2C)O[C@]1([H])O[C@H](CO)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.1.37 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

α-Chaconineα​Chaconineα ​ChaconineRNASynthesisRNA SynthesisILReceptorIL ReceptorDNASynthesisDNA SynthesisCOXAP-1a-Chaconine
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