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NKY80

Name: NKY80
Brand: TargetMol
SKU: T16333
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16333Cas No. 299442-43-6

Alias Adenylyl cyclase type V Inhibitor

NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively).

NKY80

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Purity: 99.88%

Catalog No. T16333Alias Adenylyl cyclase type V InhibitorCas No. 299442-43-6

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$62	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$343	In Stock
100 mg	$523	In Stock
200 mg	$753	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Purity:99.88%

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Product Introduction

Bioactivity

Description	NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively).
Targets&IC50	AC type V:8.3 μM, AC type II:1.7 mM, AC type III:132 μM
In vitro	NKY80 (20 μM) blocks the increase in LVP and ventricular cAMP levels[2]. NKY80 (20 μM; 2 hours) completely blocks the elevations in both cAMP content and renin release from isolated JG cells[3].
Synonyms	Adenylyl cyclase type V Inhibitor

Chemical Properties

Molecular Weight	229.23
Formula	C₁₂H₁₁N₃O₂
Cas No.	299442-43-6
Smiles	NC1=NC2=C(C=N1)C(=O)CC(C2)C1=CC=CO1
Relative Density.	1.360 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (981.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3624 mL	21.8122 mL	43.6243 mL	218.1215 mL
5 mM	0.8725 mL	4.3624 mL	8.7249 mL	43.6243 mL
10 mM	0.4362 mL	2.1812 mL	4.3624 mL	21.8122 mL
20 mM	0.2181 mL	1.0906 mL	2.1812 mL	10.9061 mL
50 mM	0.0872 mL	0.4362 mL	0.8725 mL	4.3624 mL
100 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1812 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc