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Anti-Caspase-8 Antibody (8B784)
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Catalog No. TMAC-00590
Alias OTTHUMP00000206582, OTTHUMP00000206552, OTTHUMP00000165064, OTTHUMP00000165063, OTTHUMP00000165062, OTTHUMP00000163725, OTTHUMP00000163724, OTTHUMP00000163720, OTTHUMP00000163717, MORT1 associated CED 3 homolog, MGC78473, MCH5, MCH 5, MACH beta 1/2/3/4 protein, MACH alpha 1/2/3 protein, MACH, ICE like apoptotic protease 5, FLJ17672, FLICE, FADD-like ICE, FADD-homologous ICE/ced-3-like protease, FADD Like ICE, FADD Homologous ICE/CED3 Like Protease, FADD homologous ICE/CED 3 like protease, CED 3, Caspase-8 subunit p18, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase 8, CASP8, CASP 8, CAP4, CAP 4, Apoptotic protease Mch-5, Apoptotic protease Mch 5, Apoptotic cysteine protease, Apoptosis related cysteine peptidase, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, ALPS2B
Anti-Caspase-8 Antibody (8B784) is a Rabbit antibody targeting Caspase-8. Anti-Caspase-8 Antibody (8B784) can be used in WB,ICC/IF,IHC.
Anti-Caspase-8 Antibody (8B784)
Anti-Caspase-8 Antibody (8B784)
😃Good
Catalog No. TMAC-00590Alias OTTHUMP00000206582, OTTHUMP00000206552, OTTHUMP00000165064, OTTHUMP00000165063, OTTHUMP00000165062, OTTHUMP00000163725, OTTHUMP00000163724, OTTHUMP00000163720, OTTHUMP00000163717, MORT1 associated CED 3 homolog, MGC78473, MCH5, MCH 5, MACH beta 1/2/3/4 protein, MACH alpha 1/2/3 protein, MACH, ICE like apoptotic protease 5, FLJ17672, FLICE, FADD-like ICE, FADD-homologous ICE/ced-3-like protease, FADD Like ICE, FADD Homologous ICE/CED3 Like Protease, FADD homologous ICE/CED 3 like protease, CED 3, Caspase-8 subunit p18, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase 8, CASP8, CASP 8, CAP4, CAP 4, Apoptotic protease Mch-5, Apoptotic protease Mch 5, Apoptotic cysteine protease, Apoptosis related cysteine peptidase, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, ALPS2B
Anti-Caspase-8 Antibody (8B784) is a Rabbit antibody targeting Caspase-8. Anti-Caspase-8 Antibody (8B784) can be used in WB,ICC/IF,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-Caspase-8 Antibody (8B784) is a Rabbit antibody targeting Caspase-8. Anti-Caspase-8 Antibody (8B784) can be used in WB,ICC/IF,IHC. |
| Alias | OTTHUMP00000206582, OTTHUMP00000206552, OTTHUMP00000165064, OTTHUMP00000165063, OTTHUMP00000165062, OTTHUMP00000163725, OTTHUMP00000163724, OTTHUMP00000163720, OTTHUMP00000163717, MORT1 associated CED 3 homolog, MGC78473, MCH5, MCH 5, MACH beta 1/2/3/4 protein, MACH alpha 1/2/3 protein, MACH, ICE like apoptotic protease 5, FLJ17672, FLICE, FADD-like ICE, FADD-homologous ICE/ced-3-like protease, FADD Like ICE, FADD Homologous ICE/CED3 Like Protease, FADD homologous ICE/CED 3 like protease, CED 3, Caspase-8 subunit p18, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase 8, CASP8, CASP 8, CAP4, CAP 4, Apoptotic protease Mch-5, Apoptotic protease Mch 5, Apoptotic cysteine protease, Apoptosis related cysteine peptidase, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, ALPS2B |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of Caspase-8 on different lysates using anti-Caspase-8 antibody at 1/1,000 dilution. Positive control: Lane 1: Jurkat, Lane 2: Hela. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Caspase-8 antibody. Counter stained with hematoxylin. 3. ICC staining Caspase-8 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Caspase-8 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Caspase-8 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:1000-5000; IHC: 1:50-200; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A and mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex (DISC), which activates caspase-8. The actived protein is released from the complex and further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 55 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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