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c-Kit/CD117 Protein, Human, Recombinant (hFc)
(Synonyms: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast/stem cell growth factor receptor Kit, KIT, CD117) Copy Product InfoSynonyms: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast/stem cell growth factor receptor Kit, KIT, CD117
Catalog No. TMPJ-00402 Copy Product Info
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $42 | 35 days | 35 days | |
| 10 μg | $64 | 35 days | 35 days | |
| 20 μg | $98 | 35 days | 35 days | |
| 50 μg | $200 | 35 days | 35 days | |
| 100 μg | $375 | 35 days | 35 days | |
| 200 μg | $696 | 35 days | 35 days | |
| 500 μg | $1,670 | 35 days | 35 days | |
| 1 mg | $2,510 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P10721 |
| Amino Acid | Gln26-Thr520 |
| Construction | Gln26-Thr520 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Tyrosine-protein kinase Kit, SCFR, Proto-oncogene c-Kit, Piebald trait protein, PBT, p145 c-kit, Mast/stem cell growth factor receptor Kit, KIT, CD117 |
| Research Background |
| Molecular Weight | 100-140 kDa (reducing condition) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: c-Kit/CD117 Protein, Human, Recombinant (hFc) chemical structure | c-Kit/CD117 Protein, Human, Recombinant (hFc) molecular weight
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