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CD117 Protein, Human, Recombinant (hFc)

Catalog No. TMPJ-00402
Synonyms: KIT, CD117, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, p145 c-kit, SCFR, Tyrosine-protein kinase Kit, Proto-oncogene c-Kit, Mast/stem cell growth factor receptor Kit, PBT, Piebald trait protein

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD117 Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 64.00
50 μg 5 days $ 200.00
500 μg 5 days $ 1,670.00
1 mg 5 days $ 2,510.00
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Biological Description
Technical Params
Product Properties
Description C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
Species Human
Expression System Human Cells
Tag C-Fc
Accession Number P10721
Synonyms KIT, CD117, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, p145 c-kit, SCFR, Tyrosine-protein kinase Kit, Proto-oncogene c-Kit, Mast/stem cell growth factor receptor Kit, PBT, Piebald trait protein
Amino Acid Gln26-Thr520
Construction Recombinant Human Mast/stem Cell Growth Factor Receptor Kit is produced by our Mammalian expression system and the target gene encoding Gln26-Thr520 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 100-140 kDa, reducing conditions
Endotoxin Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

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Keywords

CD117 Protein, Human, Recombinant (hFc) KIT CD117 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog p145 c-kit SCFR CD 117 Tyrosine-protein kinase Kit Proto-oncogene c-Kit CD-117 Mast/stem cell growth factor receptor Kit PBT Piebald trait protein recombinant recombinant-proteins proteins protein

 

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