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Anti-HIF-1 beta Antibody (7D594)
😃Good
Catalog No. TMAB-07029
Anti-HIF-1 beta Antibody (7D594) is a Rabbit antibody targeting HIF-1 beta. Anti-HIF-1 beta Antibody (7D594) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF.
Anti-HIF-1 beta Antibody (7D594)
Anti-HIF-1 beta Antibody (7D594)
😃Good
Catalog No. TMAB-07029
Anti-HIF-1 beta Antibody (7D594) is a Rabbit antibody targeting HIF-1 beta. Anti-HIF-1 beta Antibody (7D594) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HIF-1 beta Antibody (7D594) is a Rabbit antibody targeting HIF-1 beta. Anti-HIF-1 beta Antibody (7D594) can be used in WB,IHC-P,IHC-Fr,IF,ICC/IF. |
| Ig Type | IgG |
| Clone | 7D594 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Immunogen | A synthesized peptide: human HIF 1 beta |
| Antigen Species | Human |
| Gene Name | ARNT |
| Gene ID | |
| Protein Name | Aryl hydrocarbon receptor nuclear translocator |
| Uniprot ID | |
| Function | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. |
| Molecular Weight | Theoretical: 87 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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