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DDX3-IN-2

Name: DDX3-IN-2
Brand: TargetMol
SKU: T61193
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61193Cas No. 1919828-81-1

DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.

DDX3-IN-2

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Catalog No. T61193Cas No. 1919828-81-1

DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.
Targets&IC50	DEADbox polypeptide 3 (DDX3):0.3 μM
In vitro	DDX3-IN-2 is a competitive inhibitor of RNA substrates, and its inhibitory potency decreases with increasing RNA substrate concentration. DDX3-IN-2 was shown to be a potent inhibitor of DEADbox polypeptide 3 (DDX3) with an IC50 of 0.3 μM, and DDX3-IN-2 was inactive against the ATPase activity of DDX3, DDX1 deconjugating enzyme and DENV NS3 deconjugating enzyme. [1]
In vivo	In animal studies, DDX3-IN-2 was administered via tail vein injection at a dose of 20 mg/kg, which showed good biocompatibility and was well tolerated by Wistar rats. DDX3-IN-2 rapidly shortens the half-life and decreases plasma clearance in an intravenous push (0-25 hours) at a dose of 10 mg/kg. [1]

Chemical Properties

Molecular Weight	349.43
Formula	C₂₀H₂₃N₅O
Cas No.	1919828-81-1
Smiles	O=C(NC1=CC=C(C=C1)N2N=NC(=C2)CCCC)NC=3C=CC=CC3C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (228.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8618 mL	14.3090 mL	28.6180 mL	143.0902 mL
5 mM	0.5724 mL	2.8618 mL	5.7236 mL	28.6180 mL
10 mM	0.2862 mL	1.4309 mL	2.8618 mL	14.3090 mL
20 mM	0.1431 mL	0.7155 mL	1.4309 mL	7.1545 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8618 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4309 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc