Shopping Cart
Remove All
Your shopping cart is currently empty
PF-04937319
Copy Product Info
🥰Excellent
Catalog No. T16479Cas No. 1245603-92-2
PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be used in research on the treatment of type 2 diabetes mellitus.
PF-04937319
Copy Product Info🥰Excellent
Purity: 99.89%
Catalog No. T16479Cas No. 1245603-92-2
PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be used in research on the treatment of type 2 diabetes mellitus.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $38 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $155 | In Stock | In Stock | |
| 25 mg | $322 | In Stock | In Stock | |
| 50 mg | $587 | In Stock | In Stock | |
| 100 mg | $855 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.89%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
PF-04937319 AI Summary
PF-04937319 is a multifaceted bioactive compound demonstrating diverse biological activities across several systems. It notably activates human recombinant glucokinase and promotes glucokinase translocation from the nucleus to the cytoplasm in rat hepatocytes. The compound shows enhanced drug uptake via human hepatic OATP1B1 and OATP1B3 transporters and possesses apparent permeability across dog RRCK cells. Its lipophilicity, with a LogD7.4 value of 2.1, suggests favorable bioavailability and interaction potential with lipid bilayers.
In pharmacokinetic studies, PF-04937319 exhibits a high fraction unbound in rat plasma. It shows activation of glucokinase by increasing enzyme velocity and altering the glucokinase Km, with an EC50 of 190.0 nM in a glucose-present assay. The compound also demonstrates antidiabetic potential in Sprague-Dawley rats and exhibits a therapeutic index greater than 5.0. It has demonstrated antiviral activity against SARS-CoV-2, reducing cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 μM, although with varying inhibitory percentages.
Additionally, PF-04937319 shows inhibition of the SARS-CoV-2 3CL-Pro protease and exhibits minor inhibitory activity on human HDAC6. With its diverse bioactivities, particularly in glucose metabolism regulation, antiviral properties, and high permeability, PF-04937319 is a promising candidate for further pharmacological exploration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be used in research on the treatment of type 2 diabetes mellitus. |
| Targets&IC50 | GK:154.4 μM(EC50) |
| Molecular Weight | 432.43 |
| Formula | C22H20N6O4 |
| Cas No. | 1245603-92-2 |
| Smiles | CN(C)C(=O)c1ncc(Oc2cc(cc3oc(C)cc23)C(=O)Nc2cnc(C)cn2)cn1 |
| Relative Density. | 1.366 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 95 mg/mL (219.69 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy PF-04937319 | purchase PF-04937319 | PF-04937319 cost | order PF-04937319 | PF-04937319 chemical structure | PF-04937319 formula | PF-04937319 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.