Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Carnostatine hydrochloride

Name: Carnostatine hydrochloride
Brand: TargetMol
SKU: T10684L
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T10684L

Alias SAN9812 hydrochloride

Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective inhibitor of carnosinase 1 (CN1), with a K_i of 11 nM against human recombinant CN1, showing promise for the treatment of diabetic nephropathy (DN) [1].

Carnostatine hydrochloride

Copy Product Info

😃Good

Catalog No. T10684LAlias SAN9812 hydrochloride

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	1-2 weeks	1-2 weeks
50 mg	$1,980	1-2 weeks	1-2 weeks
100 mg	$2,500	1-2 weeks	1-2 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective inhibitor of carnosinase 1 (CN1), with a K_i of 11 nM against human recombinant CN1, showing promise for the treatment of diabetic nephropathy (DN) [1].
Targets&IC50	CN1 (human):ki： 11 nM
In vitro	Carnostatine inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. At a carnosine concentration of 200 μM, Carnostatine has an IC 50 value of 18 nM on human recombinant CN1, i.e., close to the K m of 190 μM [1].
In vivo	Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) in human CN1 transgenic (TG) mice results in a sustained reduction in circulating CN1 activity. Simultaneous administration of Carnosine and Carnostatine significantly increases carnosine levels in plasma and kidney, up to 100-fold compared to untreated CN1-overexpressing mice [1]. Animal Model: Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background [1] Dosage: 3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis) Administration: Single bolus administration Result: Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Synonyms	SAN9812 hydrochloride

Chemical Properties

Molecular Weight	292.72
Formula	C₁₀H₁₇ClN₄O₄
Smiles	OC([C@@H](NC([C@@H](O)CCN)=O)CC1=CNC=N1)=O.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (854.06 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.4162 mL	17.0812 mL	34.1623 mL	170.8117 mL
5 mM	0.6832 mL	3.4162 mL	6.8325 mL	34.1623 mL
10 mM	0.3416 mL	1.7081 mL	3.4162 mL	17.0812 mL
20 mM	0.1708 mL	0.8541 mL	1.7081 mL	8.5406 mL
50 mM	0.0683 mL	0.3416 mL	0.6832 mL	3.4162 mL
100 mM	0.0342 mL	0.1708 mL	0.3416 mL	1.7081 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SAN-9812 HydrochlorideSAN9812 HydrochlorideSAN 9812 Hydrochloridehuman CN1Carnostatine Hydrochloride