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ICAM-1-IN-1

ICAM-1-IN-1
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
Catalog No. T13147Cas No. 251994-14-6
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Purity:99.34%
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ICAM-1-IN-1

Catalog No. T13147Cas No. 251994-14-6

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$413In Stock
10 mg$618In Stock
25 mg$985In Stock
50 mg$1,330In Stock
100 mg$1,790In Stock
500 mg$3,590In Stock
1 mL x 10 mM (in DMSO)$455In Stock
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Product Introduction

Bioactivity
Description
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
Targets&IC50
Eselectin:7 nM , ICAM1:5 nM
In vivo
In both a rat model of rheumatoid arthritis and a mouse model of asthma, ICAM-1-IN-1 demonstrates significant therapeutic effects. Notably, after nine days of treatment with ICAM-1-IN-1, there is a reduction in the swelling of inflamed ankles in the rat arthritis model; however, it does not exhibit efficacy during the acute phase of the condition. A 21-day regimen of ICAM-1-IN-1 at a dosage of 25 mg/kg markedly decreases ankle inflammation in arthritic rats. Additionally, this treatment leads to a notable decrease in eosinophil counts and levels of serum-soluble ICAM-1 (sICAM-1).
Chemical Properties
Molecular Weight363.23
FormulaC15H11BrN2O2S
Cas No.251994-14-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (137.65 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7531 mL13.7654 mL27.5308 mL137.6538 mL
5 mM0.5506 mL2.7531 mL5.5062 mL27.5308 mL
10 mM0.2753 mL1.3765 mL2.7531 mL13.7654 mL
20 mM0.1377 mL0.6883 mL1.3765 mL6.8827 mL
50 mM0.0551 mL0.2753 mL0.5506 mL2.7531 mL
100 mM0.0275 mL0.1377 mL0.2753 mL1.3765 mL

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