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ICAM-1-IN-1

Name: ICAM-1-IN-1
Brand: TargetMol
SKU: T13147
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T13147 Copy Product Info

Purity: 99.67%

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ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).

ICAM-1-IN-1

Copy Product Info

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Catalog No. T13147

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).

Cas No. 251994-14-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$195	In Stock	In Stock
5 mg	$413	In Stock	In Stock
10 mg	$618	In Stock	In Stock
25 mg	$985	In Stock	In Stock
50 mg	$1,330	In Stock	In Stock
100 mg	$1,790	In Stock	In Stock
500 mg	$3,590	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$455	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.67%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
Targets&IC50	Eselectin:7 nM , ICAM1:5 nM
In vivo	In both a rat model of rheumatoid arthritis and a mouse model of asthma, ICAM-1-IN-1 demonstrates significant therapeutic effects. Notably, after nine days of treatment with ICAM-1-IN-1, there is a reduction in the swelling of inflamed ankles in the rat arthritis model; however, it does not exhibit efficacy during the acute phase of the condition. A 21-day regimen of ICAM-1-IN-1 at a dosage of 25 mg/kg markedly decreases ankle inflammation in arthritic rats. Additionally, this treatment leads to a notable decrease in eosinophil counts and levels of serum-soluble ICAM-1 (sICAM-1).

Chemical Properties

Molecular Weight	363.23
Formula	C₁₅H₁₁BrN₂O₂S
Cas No.	251994-14-6
Smiles	CNC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1
Relative Density.	1.556 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (137.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7531 mL	13.7654 mL	27.5308 mL	137.6538 mL
5 mM	0.5506 mL	2.7531 mL	5.5062 mL	27.5308 mL
10 mM	0.2753 mL	1.3765 mL	2.7531 mL	13.7654 mL
20 mM	0.1377 mL	0.6883 mL	1.3765 mL	6.8827 mL
50 mM	0.0551 mL	0.2753 mL	0.5506 mL	2.7531 mL
100 mM	0.0275 mL	0.1377 mL	0.2753 mL	1.3765 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc