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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $413 | In Stock | |
10 mg | $618 | In Stock | |
25 mg | $985 | In Stock | |
50 mg | $1,330 | In Stock | |
100 mg | $1,790 | In Stock | |
500 mg | $3,590 | In Stock | |
1 mL x 10 mM (in DMSO) | $455 | In Stock |
Description | ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM). |
Targets&IC50 | Eselectin:7 nM , ICAM1:5 nM |
In vivo | In both a rat model of rheumatoid arthritis and a mouse model of asthma, ICAM-1-IN-1 demonstrates significant therapeutic effects. Notably, after nine days of treatment with ICAM-1-IN-1, there is a reduction in the swelling of inflamed ankles in the rat arthritis model; however, it does not exhibit efficacy during the acute phase of the condition. A 21-day regimen of ICAM-1-IN-1 at a dosage of 25 mg/kg markedly decreases ankle inflammation in arthritic rats. Additionally, this treatment leads to a notable decrease in eosinophil counts and levels of serum-soluble ICAM-1 (sICAM-1). |
Molecular Weight | 363.23 |
Formula | C15H11BrN2O2S |
Cas No. | 251994-14-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (137.65 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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