Shopping Cart

Your shopping cart is currently empty

BMS-813160

Name: BMS-813160
Brand: TargetMol
SKU: T4584
Price: 57 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4584Cas No. 1286279-29-5

Alias BMS 813160

BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.

BMS-813160

Copy Product Info

🥰Excellent

Purity: 99.79%

Catalog No. T4584Alias BMS 813160Cas No. 1286279-29-5

BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$57	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$359	In Stock	In Stock
50 mg	$597	In Stock	In Stock
100 mg	$852	In Stock	In Stock
500 mg	$1,730	In Stock	-
1 mL x 10 mM (in DMSO)	$148	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.79%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BMS-813160 AI Summary

BMS-813160 exhibits bioactivities related to chemokine receptors CCR2 and CCR5. It shows potent antagonist activity at both receptors, inhibiting chemotaxis and upregulation of specific markers induced by CCL2 and MIP-1beta. The compound also demonstrates high stability in liver microsomes across different species and moderate protein binding in plasma. Additionally, it displays good oral bioavailability and clearance rates in various animal models, and its selectivity ratio for CCR2 and CCR5 displacement suggests a preference for CCR5..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
Targets&IC50	CCR2:6.2 nM, CCR5:3.6 nM
Synonyms	BMS 813160

Chemical Properties

Molecular Weight	484.64
Formula	C₂₅H₄₀N₈O₂
Cas No.	1286279-29-5
Smiles	CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C1=O)NC(C)(C)C
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (113.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0634 mL	10.3169 mL	20.6339 mL	103.1694 mL
5 mM	0.4127 mL	2.0634 mL	4.1268 mL	20.6339 mL
10 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3169 mL
20 mM	0.1032 mL	0.5158 mL	1.0317 mL	5.1585 mL
50 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL
100 mM	0.0206 mL	0.1032 mL	0.2063 mL	1.0317 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc