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AMG2850

🥰Excellent
Catalog No. T10300Cas No. 1470018-52-0

AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 [TRPM8].

AMG2850

AMG2850

🥰Excellent
Purity: 99.84%
Catalog No. T10300Cas No. 1470018-52-0
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 [TRPM8].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$68In StockIn Stock
5 mg$173In StockIn Stock
10 mg$260In StockIn Stock
25 mg$469In StockIn Stock
50 mg$696In StockIn Stock
100 mg$893In StockIn Stock
1 mL x 10 mM (in DMSO)$191In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.84%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 [TRPM8].
Chemical Properties
Molecular Weight417.35
FormulaC19H17F6N3O
Cas No.1470018-52-0
SmilesC[C@H](NC(=O)N1CCc2cccnc2[C@H]1c1ccc(cc1)C(F)(F)F)C(F)(F)F
Relative Density.1.354 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (239.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3961 mL11.9804 mL23.9607 mL119.8035 mL
5 mM0.4792 mL2.3961 mL4.7921 mL23.9607 mL
10 mM0.2396 mL1.1980 mL2.3961 mL11.9804 mL
20 mM0.1198 mL0.5990 mL1.1980 mL5.9902 mL
50 mM0.0479 mL0.2396 mL0.4792 mL2.3961 mL
100 mM0.0240 mL0.1198 mL0.2396 mL1.1980 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TRPVChannelTRPV ChannelTRPM8TRPChannelTRP ChannelTransient receptor potential channelsInhibitorinhibitAMG-2850AMG2850AMG 2850
Related Tags: buy AMG2850 | purchase AMG2850 | AMG2850 cost | order AMG2850 | AMG2850 chemical structure | AMG2850 formula | AMG2850 molecular weight
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