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Anti-TRAF6 Polyclonal Antibody
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Catalog No. TMAB-01884
Alias TRAF6, TNF receptor-associated factor 6, RNF85, RING-type E3 ubiquitin transferase TRAF6, RING finger protein 85, Interleukin-1 signal transducer, E3 ubiquitin-protein ligase TRAF6
Anti-TRAF6 Polyclonal Antibody is a Rabbit antibody targeting TRAF6. Anti-TRAF6 Polyclonal Antibody can be used in WB.
Anti-TRAF6 Polyclonal Antibody
Anti-TRAF6 Polyclonal Antibody
😃Good
Catalog No. TMAB-01884Alias TRAF6, TNF receptor-associated factor 6, RNF85, RING-type E3 ubiquitin transferase TRAF6, RING finger protein 85, Interleukin-1 signal transducer, E3 ubiquitin-protein ligase TRAF6
Anti-TRAF6 Polyclonal Antibody is a Rabbit antibody targeting TRAF6. Anti-TRAF6 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-TRAF6 Polyclonal Antibody is a Rabbit antibody targeting TRAF6. Anti-TRAF6 Polyclonal Antibody can be used in WB. |
| Synonyms | TRAF6, TNF receptor-associated factor 6, RNF85, RING-type E3 ubiquitin transferase TRAF6, RING finger protein 85, Interleukin-1 signal transducer, E3 ubiquitin-protein ligase TRAF6 |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | Sample: Lane 1: Rat Liver tissue lysates Lane 2: Rat Kidney tissue lysates Primary: Anti-TRAF6 (TMAB-01884) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kDa Observed band size: 60 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet (By similarity). Note=Found in the nuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthetic peptide: human TRAF6 |
| Antigen Species | Human |
| Gene Name | TRAF6 |
| Gene ID | |
| Protein Name | TNF receptor-associated factor 6 |
| Uniprot ID | |
| Biology Area | Associated Proteins,TRAF,TNF,TRAF,Associated Proteins,TLR Signaling,SARS Coronavirus,TNF,NFkB Pathway |
| Function | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. |
| Molecular Weight | Theoretical: 60 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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