TIE2 Protein, Human, Recombinant (hFc)

Name: TIE2 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-00642
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: VMCM1, VMCM, Tie-2, Tie2, TEK tyrosine kinase, endothelial, TEK, soluble TIE2 variant 2, soluble TIE2 variant 1, p140 TEK, hTIE2, EC 2.7.10.1, EC 2.7.10, CD202b antigen, CD202b, angiopoietin-1 receptor) Copy Product Info

Synonyms: VMCM1, VMCM, Tie-2, Tie2, TEK tyrosine kinase, endothelial, TEK, soluble TIE2 variant 2, soluble TIE2 variant 1, p140 TEK, hTIE2, EC 2.7.10.1, EC 2.7.10, CD202b antigen, CD202b, angiopoietin-1 receptor

Catalog No. TMPJ-00642 Copy Product Info

TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$39	-	In Stock
10 µg	$60	-	In Stock
20 µg	$96	-	In Stock
50 µg	$183	-	In Stock
100 µg	$289	7-10 days	7-10 days
200 µg	$465	7-10 days	7-10 days
500 µg	$869	7-10 days	7-10 days
1 mg	$1,300	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:Greater than 95% as determined by reducing SDS-PAGE.

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q02763-1
Amino Acid	Ala23-Lys745
Construction	Ala23-Lys745
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	VMCM1, VMCM, Tie-2, Tie2, TEK tyrosine kinase, endothelial, TEK, soluble TIE2 variant 2, soluble TIE2 variant 1, p140 TEK, hTIE2, EC 2.7.10.1, EC 2.7.10, CD202b antigen, CD202b, angiopoietin-1 receptor
Research Background	Tie-1/Tie (tyrosine kinase with Ig and EGF homology domains 1) and Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), which bind Tie-2 with high-affinity have been identified. Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

Chemical Properties

Molecular Weight

120-150 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.