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4-Vinylphenol

Name: 4-Vinylphenol
Brand: TargetMol
SKU: T13509
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13509Cas No. 2628-17-3

4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.

4-Vinylphenol

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Purity: 97.07%

Catalog No. T13509Cas No. 2628-17-3

4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$36	In Stock	In Stock
500 mg	$56	In Stock	In Stock
1 g	$89	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.07%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.

In vitro

4-Vinylphenol (100 µg/mL) notably enhances caspase 3 expression, effectively making CSC-enriched MDAMB-231 cells more prone to apoptosis. At concentrations of 50 and 100 µg/mL, it dramatically inhibits cell proliferation in these cells. Furthermore, 4-Vinylphenol at a range of 12.5-200 µg/mL substantially decreases cell viability in parental MDA-MB-231 cells, with an IC50 value determined at 109 µg/mL. At lower doses (0.15, 0.3 µg/mL), it diminishes sphere formation and vimentin expression in CSCs, indicative of its potential in targeting breast cancer. Notably, 4-Vinylphenol cuts down ALDH1A1 expression by half in CSC-enriched MDA-MB-231 cells[1].

Chemical Properties

Molecular Weight	120.15
Formula	C₈H₈O
Cas No.	2628-17-3
Smiles	Oc1ccc(C=C)cc1
Relative Density.	1.055g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (2080.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (27.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.3229 mL	41.6146 mL	83.2293 mL	416.1465 mL
5 mM	1.6646 mL	8.3229 mL	16.6459 mL	83.2293 mL
10 mM	0.8323 mL	4.1615 mL	8.3229 mL	41.6146 mL
20 mM	0.4161 mL	2.0807 mL	4.1615 mL	20.8073 mL
50 mM	0.1665 mL	0.8323 mL	1.6646 mL	8.3229 mL
100 mM	0.0832 mL	0.4161 mL	0.8323 mL	4.1615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc