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(R)-Nepicastat HCl

Name: (R)-Nepicastat HCl
Brand: TargetMol
SKU: T6356
Rating: 4.5 (1 reviews)

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Catalog No. T6356Cas No. 195881-94-8

Alias RS-25560-198 HCl

(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

(R)-Nepicastat HCl

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Catalog No. T6356Alias RS-25560-198 HClCas No. 195881-94-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$135	6-8 weeks	6-8 weeks
10 mg	$229	6-8 weeks	6-8 weeks
25 mg	$432	6-8 weeks	6-8 weeks
50 mg	$585	6-8 weeks	6-8 weeks
100 mg	$855	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$135	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
Targets&IC50	DBH (bovine):25.1 nM, DBH (human):18.3 nM
In vitro	(R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. [1]
In vivo	(R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). [1]
Synonyms	RS-25560-198 HCl

Chemical Properties

Molecular Weight	331.81
Formula	C₁₄H₁₅F₂N₃S·HCl
Cas No.	195881-94-8
Smiles	Cl.NCC1=CNC(=S)N1[C@@H]1CCC2=C(F)C=C(F)C=C2C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL

DMSO: 61 mg/mL (183.84 mM), Sonication is recommended.

Ethanol: <1 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0138 mL	15.0689 mL	30.1377 mL	150.6886 mL
5 mM	0.6028 mL	3.0138 mL	6.0275 mL	30.1377 mL
10 mM	0.3014 mL	1.5069 mL	3.0138 mL	15.0689 mL
20 mM	0.1507 mL	0.7534 mL	1.5069 mL	7.5344 mL
50 mM	0.0603 mL	0.3014 mL	0.6028 mL	3.0138 mL
100 mM	0.0301 mL	0.1507 mL	0.3014 mL	1.5069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc