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(R)-Nepicastat HCl

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Catalog No. T6356Cas No. 195881-94-8
Alias RS-25560-198 HCl

(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

(R)-Nepicastat HCl
Other Forms of (R)-Nepicastat HCl:

(R)-Nepicastat HCl

😃Good
Catalog No. T6356Alias RS-25560-198 HClCas No. 195881-94-8
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
Pack SizePriceAvailabilityQuantity
5 mg$1356-8 weeks
10 mg$2296-8 weeks
25 mg$4326-8 weeks
50 mg$5856-8 weeks
100 mg$8556-8 weeks
1 mL x 10 mM (in DMSO)$1356-8 weeks
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Product Introduction

Bioactivity
Description
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
Targets&IC50
DBH (bovine):25.1 nM, DBH (human):18.3 nM
In vitro
(R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro. [1]
In vivo
(R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs). [1]
SynonymsRS-25560-198 HCl
Chemical Properties
Molecular Weight331.81
FormulaC14H15F2N3S·HCl
Cas No.195881-94-8
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: <1 mg/mL
DMSO: 61 mg/mL (183.84 mM), Sonication is recommended.
Ethanol: <1 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0138 mL15.0689 mL30.1377 mL150.6886 mL
5 mM0.6028 mL3.0138 mL6.0275 mL30.1377 mL
10 mM0.3014 mL1.5069 mL3.0138 mL15.0689 mL
20 mM0.1507 mL0.7534 mL1.5069 mL7.5344 mL
50 mM0.0603 mL0.3014 mL0.6028 mL3.0138 mL
100 mM0.0301 mL0.1507 mL0.3014 mL1.5069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nepicastat HClDopamine β-hydroxylase(R)Nepicastat HCl(R) Nepicastat HCl
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