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TRAP1-IN-1

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Catalog No. T79285Cas No. 3031102-94-7

TRAP1-IN-1 (compound 35) is a selective TRAP1 inhibitor that disrupts TRAP1 tetramer stability, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.

TRAP1-IN-1

TRAP1-IN-1

😃Good
Catalog No. T79285Cas No. 3031102-94-7
TRAP1-IN-1 (compound 35) is a selective TRAP1 inhibitor that disrupts TRAP1 tetramer stability, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
TRAP1-IN-1 (compound 35) is a selective TRAP1 inhibitor that disrupts TRAP1 tetramer stability, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.
Chemical Properties
Molecular Weight866.74
FormulaC45H39F7N2O4P2
Cas No.3031102-94-7
SmilesO=C(C1=CC=C(O)C(=C1)C(=O)N2CC3=CC=C(OCCC[P+](C=4C=CC=CC4)(C=5C=CC=CC5)C=6C=CC=CC6)C=C3C2)N7CC=8C=CC=C(F)C8C7.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 160 mg/mL (184.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1537 mL5.7687 mL11.5375 mL57.6874 mL
5 mM0.2307 mL1.1537 mL2.3075 mL11.5375 mL
10 mM0.1154 mL0.5769 mL1.1537 mL5.7687 mL
20 mM0.0577 mL0.2884 mL0.5769 mL2.8844 mL
50 mM0.0231 mL0.1154 mL0.2307 mL1.1537 mL
100 mM0.0115 mL0.0577 mL0.1154 mL0.5769 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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