Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and promotes the degradation of TRAP1 client proteins. Additionally, TRAP1-IN-1 impedes mitochondrial complex I activity involved in oxidative phosphorylation OXPHOS, compromises the mitochondrial membrane potential, and augments glycolytic metabolism [1].
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Description | TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for TRAP1 compared to Grp94, destabilizes TRAP1 tetramers, and promotes the degradation of TRAP1 client proteins. Additionally, TRAP1-IN-1 impedes mitochondrial complex I activity involved in oxidative phosphorylation OXPHOS, compromises the mitochondrial membrane potential, and augments glycolytic metabolism [1]. |
Molecular Weight | 866.74 |
Formula | C45H39F7N2O4P2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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TRAP1-IN-1 Cytoskeletal Signaling Metabolism HSP inhibitor inhibit