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TWS119

Name: TWS119
Brand: TargetMol
SKU: T2166
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2166Cas No. 601514-19-6

TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation

TWS119

🥰Excellent

Purity: 99.63%

Catalog No. T2166Cas No. 601514-19-6

TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$253	In Stock	In Stock
100 mg	$437	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.63%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
Targets&IC50	GSK-3β:30 nM
In vivo	A cell population that expressed low levels of CD44 and high levels of CD62L on the cell surface when 30 mg/kg of TWS119 is administered. [4]

Chemical Properties

Molecular Weight	318.33
Formula	C₁₈H₁₄N₄O₂
Cas No.	601514-19-6
Smiles	Nc1cccc(c1)-c1cc2c(Oc3cccc(O)c3)ncnc2[nH]1
Relative Density.	1.415g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (188.48 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1414 mL	15.7070 mL	31.4139 mL	157.0697 mL
5 mM	0.6283 mL	3.1414 mL	6.2828 mL	31.4139 mL
10 mM	0.3141 mL	1.5707 mL	3.1414 mL	15.7070 mL
20 mM	0.1571 mL	0.7853 mL	1.5707 mL	7.8535 mL
50 mM	0.0628 mL	0.3141 mL	0.6283 mL	3.1414 mL
100 mM	0.0314 mL	0.1571 mL	0.3141 mL	1.5707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc