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N3-PEG4-C2-NH2

Name: N3-PEG4-C2-NH2
Brand: TargetMol
SKU: T16664
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16664Cas No. 951671-92-4

Alias PROTAC Linker 20

N3-PEG4-C2-NH2 is a PEG-type PROTAC linker that can be used in the synthesis of PROTAC molecules .This compound is a click chemistry reagent containing an Azide group.It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group,and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

N3-PEG4-C2-NH2

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Purity: 99.57%

Catalog No. T16664Alias PROTAC Linker 20Cas No. 951671-92-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$58	-	In Stock
1 g	$113	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	N3-PEG4-C2-NH2 is a PEG-type PROTAC linker that can be used in the synthesis of PROTAC molecules .This compound is a click chemistry reagent containing an Azide group.It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group,and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
In vitro	PROTACs, comprising two ligands joined by a linker—one for an E3 ubiquitin ligase and the other for the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Synonyms	PROTAC Linker 20

Chemical Properties

Molecular Weight	262.31
Formula	C₁₀H₂₂N₄O₄
Cas No.	951671-92-4
Smiles	[N-]=[N+]=NCCOCCOCCOCCOCCN
Relative Density.	1.10 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (304.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8123 mL	19.0614 mL	38.1228 mL	190.6142 mL
5 mM	0.7625 mL	3.8123 mL	7.6246 mL	38.1228 mL
10 mM	0.3812 mL	1.9061 mL	3.8123 mL	19.0614 mL
20 mM	0.1906 mL	0.9531 mL	1.9061 mL	9.5307 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	3.8123 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	1.9061 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc