Shopping Cart

Your shopping cart is currently empty

Bucladesine sodium

Name: Bucladesine sodium
Brand: TargetMol
SKU: T1418
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Hot

Catalog No. T1418Cas No. 16980-89-5

Alias Sodium dibutyryl cAMP, Dibutyryl-cAMP sodium salt, Dibutyryl-cAMP, DC2797, dbcAMP, Bucladesine sodium salt, Bucladesine

Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.

Bucladesine sodium

Copy Product Info

🥰Excellent

Hot

Purity: 99.76%

Catalog No. T1418Alias Sodium dibutyryl cAMP, Dibutyryl-cAMP sodium salt, Dibutyryl-cAMP, DC2797, dbcAMP, Bucladesine sodium salt, BucladesineCas No. 16980-89-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$79	In Stock	In Stock
200 mg	$117	In Stock	In Stock
500 mg	$193	In Stock	In Stock
2 g	$419	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.76%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.
In vitro	METHODS: Human eosinophil EoL-1 cells were treated with Bucladesine sodium (10-100 µM) for 8 days and activity was measured using PKA assay. RESULTS: Proliferation of EoL-1 cells treated with Bucladesine sodium increased in a time-dependent manner. [1] METHODS: PC12 cells were treated with Bucladesine sodium (1 mM) for 72 h. TNF-α levels were measured by ELISA assay. RESULTS: Bucladesine sodium increased the activity of PKA. [2]
In vivo	METHODS: To study the anti-inflammatory activity in vivo, Bucladesine sodium (0.24-0.7 µg/kg) was administered intraperitoneally to a mouse model of copper pine demyelination once daily for seven days. RESULTS: Bucladesine had a protective effect on myelin formation. Enhanced intracellular cAMP prevented demyelination and exerted anti-inflammatory and anti-apoptotic properties in a mouse model of copper pine demyelination. [3] METHODS: To investigate the effects on liver injury, Bucladesine sodium (0.5-500 mg/kg) was intraperitoneally injected into C57BL/6J jcl mice, and liver injury was induced by the intravenous injection of rTNF-α (1.0 µg/kg) and intraperitoneal injection of D-gal (500 mg/kg) after 1 h. The RESULTS showed that Bucladesine protected against hepatic injury in C57BL/6J jcl mice. RESULTS: Bucladesine protected mice from TNF-α/D-gal-induced liver injury.Bucladesine significantly enhanced the expression of Hsp70 in hepatocytes of D-gal/TNFα-injected mice, which was closely related to the inhibition of liver injury. [4]
Animal Research	Animal: Mice. Formulation: water/DMSO (9:1). Dosages: 600 nM. Administration: i.p.
Synonyms	Sodium dibutyryl cAMP, Dibutyryl-cAMP sodium salt, Dibutyryl-cAMP, DC2797, dbcAMP, Bucladesine sodium salt, Bucladesine

Chemical Properties

Molecular Weight	491.37
Formula	C₁₈H₂₃N₅NaO₈P
Cas No.	16980-89-5
Smiles	[NaH].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1OC(=O)CCC
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200 mg/mL (407.03 mM), Sonication is recommended.

DMSO: 144 mg/mL (293.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0351 mL	10.1756 mL	20.3513 mL	101.7563 mL
5 mM	0.4070 mL	2.0351 mL	4.0703 mL	20.3513 mL
10 mM	0.2035 mL	1.0176 mL	2.0351 mL	10.1756 mL
20 mM	0.1018 mL	0.5088 mL	1.0176 mL	5.0878 mL
50 mM	0.0407 mL	0.2035 mL	0.4070 mL	2.0351 mL
100 mM	0.0204 mL	0.1018 mL	0.2035 mL	1.0176 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc