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Biotin-PEG4-SH

Name: Biotin-PEG4-SH
Brand: TargetMol
SKU: T210526
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T210526 Copy Product Info

Purity: 99.82%

🥰Excellent

Biotin-PEG4-SH is a PEG-based PROTAC Linker containing a biotin group and a thiol (SH) moiety. Composed of four ethylene glycol units, it offers excellent hydrophilicity and is frequently utilized in the synthesis of PROTACs. The thiol group allows for conjugation with target protein ligands or E3 ubiquitin ligase ligands via thiol-maleimide coupling or disulfide exchange. The biotin group facilitates the enrichment, detection, or further bioconjugation of the resulting molecules.

Biotin-PEG4-SH

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Catalog No. T210526

Cas No. 2762393-22-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$98	-	In Stock
5 mg	$215	-	In Stock
10 mg	$348	-	In Stock
25 mg	$697	-	In Stock
50 mg	$1,050	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	479.65
Formula	C₂₀H₃₇N₃O₆S₂
Cas No.	2762393-22-4
Smiles	C(CCCC(NCCOCCOCCOCCOCCS)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (166.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0849 mL	10.4243 mL	20.8485 mL	104.2427 mL
5 mM	0.4170 mL	2.0849 mL	4.1697 mL	20.8485 mL
10 mM	0.2085 mL	1.0424 mL	2.0849 mL	10.4243 mL
20 mM	0.1042 mL	0.5212 mL	1.0424 mL	5.2121 mL
50 mM	0.0417 mL	0.2085 mL	0.4170 mL	2.0849 mL
100 mM	0.0208 mL	0.1042 mL	0.2085 mL	1.0424 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc